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The No. 21 Arizona Wildcats (6-3) will try to extend their three-game winning streak when they face the Colorado Buffaloes (4-5) on Saturday afternoon. Arizona has taken down three consecutive ranked opponents, including a 27-10 win over then-No. 19 UCLA last week. The Wildcats have not been on the road since their 44-6 win at then-No. 19 Washington State to kickstart their current winning streak last month. Colorado is trying to get back to the .500 mark after dropping three straight games under first-year coach Deion Sanders.

Kickoff is at 2 p.m. ET from Folsom Field in Boulder. The latest SportsLine consensus Colorado vs. Arizona odds list the Wildcats at -9.5, while the over/under for total points is 54.5. Before entering any Arizona vs. Colorado picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on Arizona vs. Colorado. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • Colorado vs. Arizona spread: Arizona -9.5
  • Colorado vs. Arizona over/under: 54.5 points
  • Colorado vs. Arizona money line: Arizona -366, Colorado +283
  • Colorado vs. Arizona picks: See picks here
  • Colorado vs. Arizona live stream: fubo (try for free)

Why Arizona can cover

Arizona has been a covering machine this season with an 8-1 ATS mark. Balance has been key for the Wildcats, who rank fifth in the Pac-12 in both total offense and defense. The defense has been extremely tough to run on as it is giving up only around 100 yards per game on the ground.

Redshirt freshman quarterback Noah Fifita has been a huge boost to the offense and he's been helped by an impressive group of skill players. Receivers Tetairoa McMillan (52-753-7) and Jacob Cowing (69-510-9) comprise one of the conference's top WR duos. Tight end Tanner McLachlan (31-389-2) has been solid, and running back Jonah Coleman (93-565-3) ranks eighth in the Pac-12 in rushing. See which team to pick here. 

Why Colorado can cover

While Colorado has lost three straight games and five of its last six, the Buffaloes have been competitive against ranked teams. They covered the spread as 13-point underdogs in their 26-19 loss to Oregon State last week, scoring 14 points in the fourth quarter of that setback. That came one week after their 28-16 loss to UCLA, where the Buffaloes covered the spread as 14-point road underdogs.

Junior quarterback Shedeur Sanders leads Colorado's offense with 2,882 passing yards, 24 touchdowns and three interceptions, racking up 300 yards in five games this season. Arizona has lost two of its four road games, while one of its road wins came by just one point at Stanford in September. The Wildcats are in a letdown spot following three wins over ranked opponents, especially since they have a game against No. 18 Utah looming next week.  See which team to pick here. 

How to make Arizona vs. Colorado picks

The model has simulated Colorado vs. Arizona 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Colorado vs. Arizona, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Wildcats vs. Buffaloes spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.