In a game that was originally scheduled to be held in Baton Rouge, the Missouri Tigers will host the No. 17 LSU Tigers at Faurot Field on Saturday. Kickoff is set for noon ET. The projected path of Hurricane Delta forced the move earlier in the week. The LSU vs. Missouri odds from William Hill swung in a big way as a result. 

LSU opened as a 20.5-point favorite, but is now listed at -14.5 on the road. The over-under for total points is set at 54. Missouri (0-2) is looking for its first win and cover of the season. LSU, meanwhile, is 1-1 both straight-up and against the spread. Before making any Missouri vs. LSU picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,200 for $100 players on its top-rated college football picks against the spread. It is a sizzling 20-3 on top-rated picks through five weeks of the 2020 college football season, returning over $1,300 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on LSU vs. Missouri. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Missouri vs. LSU:

  • LSU vs. Missouri spread: LSU -14.5
  • LSU vs. Missouri over-under: 54 points
  • LSU vs. Missouri money line: LSU -600, Missouri +450
  • LSU: The Tigers have covered in four straight games on artificial turf.
  • MIZZ: The Tigers are 13-6 against the spread in their last 19 home games.

Why LSU can cover

After losing to Mississippi State (+16.5) as a big favorite in its opener, LSU bounced back and routed Vanderbilt 41-7 in Nashville last week, covering as a 20.5-point favorite. With a vastly different roster than the team that won the national championship last year, the Tigers were bound to have some growing pains early in the season. They seemed to settle in, however, against a Vanderbilt squad that gave Texas A&M huge issues in that matchup two weeks ago.

Quarterback Myles Brennan threw for 337 yards, four touchdowns and just one interception against the Commodores. With starting running back Chris Curry out for undisclosed reasons, sophomore John Emery Jr. stepped in and posted a strong 12-103-1 rushing line. Coach Ed Orgeron said Curry could return this week, giving LSU plenty of options in the backfield. 

Why Missouri can cover

This is the third consecutive game against a Top 25 team for the Tigers, as No. 2 Alabama beat Missouri 38-19 in the opener and No. 21 Tennessee defeated the Tigers 35-12 last weekend.

The Tigers' offense has failed to be as productive as coach Eli Drinkwitz's units were at Appalachian State, as Missouri has scored just 31 points in losses to the Crimson Tide and Volunteers. Drinkwitz has employed a two-quarterback strategy in both games, starting Shawn Robinson and bringing Connor Bazelak in off the bench. Bazelak seemed to give the offense a boost against Tennessee last week and is expected to get the start on Saturday. 

How to make LSU vs. Missouri picks

SportsLine's model is leaning under on the total, as both starting quarterbacks combine for only three touchdown passes and two interceptions in the simulations. It has also generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the pick at SportsLine

So who wins LSU vs. Missouri? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the Missouri vs. LSU spread to back, all from the advanced model that is up over $4,200 on its top-rated college football spread picks, and find out.