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The Houston Astros welcome the New York Mets to Minute Maid Park for a high-profile matchup on Wednesday afternoon. Both teams are leading their respective divisions as the 2022 season continues, adding intrigue to the contest. The matchup is the second game of a two-game midweek series. The Mets lost the first matchup to slip to 45-25 overall, while the Astros are now 42-25 this season.

Caesars Sportsbook lists the Astros as -135 money line favorites, and first pitch is scheduled for 2:10 p.m. ET. The total number of runs Vegas thinks will be scored, or the over-under, is eight in the latest Astros vs. Mets odds. Before you make any MLB predictions with the Mets vs. Astros match-up, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Mets vs. Astros, and just locked in its picks and MLB predictions. You can head to SportsLine to see its picks. Here are several MLB odds and betting lines for Astros vs. Mets:

  • Mets vs. Astros money line: Astros -135, Mets +115
  • Mets vs. Astros over-under: 8 runs
  • Mets vs. Astros run line: Astros -1.5 (+145)
  • Mets vs. Astros tickets: See tickets at StubHub
  • NYM: The Mets are 20-9 in day games
  • HOU: The Astros are 17-8 in day games
Featured Game | Houston Astros vs. New York Mets

Why you should back the Mets

The Mets are enjoying considerable success in 2022. New York entered the series against Houston with NL-leading marks in runs scored, hits, triples, batting average, and on-base percentage this season. The Mets are also strongly above-average in avoiding strikeouts on offense, and New York's lineup has been highly productive. 

On the run prevention side, the Mets will deploy Carlos Carrasco as the starting pitcher on Wednesday, and the veteran right-hander has a 3.74 ERA since May 1 and an ERA below 4.00 for the full season. Carrasco is averaging a strikeout per inning, issuing only 1.9 walks per nine innings, and allowing only 0.7 home runs per nine innings this season. Carrasco is backed by an above-average bullpen from a statistical perspective, and he has a 3.69 career ERA in starts against the Astros.

Why you should back the Astros

Minute Maid Park provides home-field advantage for the Astros, and Houston's offense is powerful in nature. The Astros entered this week's series against the Mets with the second-most home runs (87) in the American League, and Houston ranks in the top three of the AL in both walks and strikeout avoidance. The Astros are slugging well over .400 as a team this season, with top-five marks in on-base percentage and OPS.

Houston can also take solace in starting pitcher Luis Garcia, who is rock solid. Garcia finished No. 2 in AL Rookie of the Year voting in 2021, and he owns a sparkling career ERA of 3.43. Garcia's 3.41 ERA is strong this season, and it dips to 3.05 since May 1. Garcia is averaging more than a strikeout per inning in 2022, and he has a 1.03 WHIP to go along with a .654 OPS allowed to opposing hitters.

How to make Astros vs. Mets picks

SportsLine's model is leaning over on the total, projecting 9.2 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Mets vs. Astros? And which side has all the value? Visit SportsLine now to which side of Astros vs. Mets you need to jump on Wednesday, all from the model that has crushed its MLB picks, and find out.