Wrigley Field hosts an inter-league matchup between historic MLB franchises on Friday. The Chicago Cubs (30-46) host the Boston Red Sox (43-33) in the first contest of a three-game series. Chicago is struggling this season, but Boston is red-hot as the team arrives. The Red Sox posted a 20-6 record in June and had two separate win streaks of seven games in the month.

Caesars Sportsbook lists the Red Sox as -145 money line favorites, and first pitch is scheduled for 2:20 p.m. ET. The total number of runs Vegas thinks will be scored, or the over-under, is 8.5 in the latest Cubs vs. Red Sox odds. Before you make any MLB predictions with the Red Sox vs. Cubs match-up, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves as one of three best bets to win it all last season at +1000. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Red Sox vs. Cubs, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Cubs vs. Red Sox:

  • Red Sox vs. Cubs money line: Red Sox -145, Cubs +122
  • Red Sox vs. Cubs over-under: 8.5 runs
  • Red Sox vs. Cubs run line: Red Sox -1.5 (+118)
  • BOS: The Red Sox are 14-13 in day games
  • CHI: The Cubs are 14-15 in day games
  • Red Sox vs. Cubs picks: See picks here
Featured Game | Chicago Cubs vs. Boston Red Sox

Why you should back the Red Sox

In addition to a powerful and effective offense, Boston's run prevention projects to be effective on Friday. Veteran left-hander Rich Hill is scheduled to start for the Red Sox, and he has a 3.23 ERA over the last eight seasons. Hill also posted a 3.00 ERA in June, and he has a 2.50 ERA on the road this season. Left-handed batters are posting only a .628 OPS against the southpaw in 2022, and Hill boasts a career 1.74 ERA against the Cubs.

Boston's bullpen is also a strength, with Red Sox relievers combining for a 3.74 ERA this season. Boston's relief corps also rank above the AL average in wins above replacement and strikeout rate. The Red Sox clearly holds the offensive advantage over the Cubs with top-three marks in the AL in runs scored, hits, batting average, OPS, and total bases, and Boston's lineup is deep and talented.

Why you should back the Cubs

Chicago projects well from a pitching standpoint on Friday. The Cubs will send 30-year-old right-hander Adrian Sampson to the mound, and he has a 1.69 ERA this season. That lights-out performance speaks for itself, and Sampson owns a 2.54 ERA over the last two seasons. He has walked only 2.0 batters per nine innings over that larger sample, and opponents have an ugly .476 OPS against Sampson this season. 

Chicago's bullpen is also stout in a few key areas, including a strikeout rate of more than 10 strikeouts per nine innings. That ranks in the top three of the National League among relief corps, and Chicago is soundly above the NL average in doubles, triples, stolen bases, walks and on-base percentage this season.

How to make Cubs vs. Red Sox picks

SportsLine's model is leaning over on the total, projecting 10.1 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Red Sox vs. Cubs? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.