The AL Central takes the stage on Monday afternoon with a divisional matchup. The Chicago White Sox visit the Detroit Tigers in the 16th game between the two teams this season. Chicago has already clinched the division title, and the White Sox toppled the Cleveland Indians on Sunday. Detroit lost a home game to the Kansas City Royals, falling to 75-80 on the season.

First pitch is set for 1:10 p.m. ET in Detroit. The latest White Sox vs. Tigers odds from Caesars Sportsbook list Chicago as the -153 favorite (risk $153 to win $100), with Detroit going off as the +143 underdog. The over-under for total runs is set at 9.5. Before locking in any Tigers vs. White Sox picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

This model, which simulates every game 10,000 times, is 193-164 on top-rated MLB money-line picks through 25 weeks in the 2021 season, returning over $500. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. Anyone following it has seen some huge returns.

Now, the model has set its sights on White Sox vs. Tigers and just revealed its picks and predictions. You can head to SportsLine now to see its picks. Now, here are several MLB odds and betting trends for Tigers vs. White Sox:

  • White Sox vs. Tigers money line: White Sox -153, Tigers +143
  • White Sox vs. Tigers over-under: 9.5 runs
  • White Sox vs. Tigers run line: White Sox -1.5
  • CHW: The White Sox are 39-41 on the road in 2021
  • DET: The Tigers are 42-38 in home games this season
Featured Game | Detroit Tigers vs. Chicago White Sox

Why you should back the White Sox

Despite some shaky-season long numbers (8-9, 5.18 ERA), White Sox starter Dallas Keuchel has only given up four earned runs over his past 11 innings. He's battling for a spot on Chicago's postseason roster, so you can expect him to be locked in for this particular start. 

From there, Chicago will hand the ball to a bullpen that ranks No. 2 in the American League in wins above replacement. Chicago's relief corps owns the best strikeout rate in the AL, punching out 10.61 batters per 9 innings, and they also have a top-flight mark in ERA at only 3.93 this season. Given that Tigers starting pitcher Matt Manning has a 5.73 ERA this season and a 6.62 ERA in September, the advantage trends to Chicago.

Why you should back the Tigers

Chicago is strong offensively, but the White Sox are a bottom-10 team in MLB in home runs (179), and Manning has enjoyed some success in recent days. Detroit's starting pitcher for Monday has allowed three earned runs or fewer in eight of his nine home starts this season, and the Tigers are 2-0 against the White Sox in games started by Manning this season. 

Offensively, Detroit leads the American League with 34 triples, and that team speed also manifests into a top-10 mark in all of baseball with 77 stolen bases in 2021. Keuchel gave up 11 hits in his last five-inning outing and walked five in his prior start, so there should be some opportunities to get players on base. 

How to make Tigers vs. White Sox picks

SportsLine's model is leaning under the total, projecting 9.3 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins White Sox vs. Tigers? And which side has all the value? Visit SportsLine now to find out which side you need to jump on, all from the model that has crushed its MLB picks, and find out.