NBA: Milwaukee Bucks at Philadelphia 76ers
Bill Streicher / USA TODAY Sports

Two Eastern Conference teams dealing with multiple injuries will lock up on Wednesday night as the Cleveland Cavaliers (13-8) host the Philadelphia 76ers (12-9). Philly is still without the services of James Harden and Tyrese Maxey, both of whom have foot injuries. Meanwhile, the Cavs will be down big men Jarrett Allen (back) and Kevin Love (thumb). These teams have yet to play this season, but the Sixers swept the four-game regular season series last year.

Tip-off is set for 7 p.m. ET from Rocket Mortgage FieldHouse in Cleveland. The latest Cavaliers vs. 76ers odds from Caesars Sportsbook have the Cavs as 3.5-point home favorites, with the over-under set at 210. Before entering any 76ers vs. Cavaliers picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past four-plus seasons. The model enters Week 7 of the 2022-23 NBA season on a stunning 106-70 roll on all top-rated NBA picks that dates back to last season, returning more than $2,800. Anyone following it has seen huge returns.

Now, the model has set its sights on Cavaliers vs. 76ers. You can head to SportsLine to see its picks. Here are several NBA betting lines for 76ers vs. Cavaliers:

  • Cavaliers vs. 76ers spread: Cavaliers -3.5
  • Cavaliers vs. 76ers over/under: 210 points
  • Cavaliers vs. 76ers money line: Cleveland -165, Philadelphia +140
  • Cavaliers vs. 76ers picks: See picks here
Featured Game | Cleveland Cavaliers vs. Philadelphia 76ers

What you need to know about the Cavaliers

The Toronto Raptors got several players that had been hurt back on the floor just in time to hand Cleveland its second loss in three games on Monday, 100-88. The Cavs still got a pair of 18-point performances from Darius Garland, who also had 10 assists, and Evan Mobley, who grabbed 15 rebounds. Cleveland's other three starters; Donovan Mitchell, Dean Wade and Isaac Okoro combined to go 7-for-32 from the field.

Something that has been failing Cleveland in recent games has been its results around the three-point line on both ends of the floor. Over their last three outings, the Cavs have made just 27.3% of their three-pointers but allowed opponents to hit 39.8% of their attempts. Without Allen and Love, Philadelphia should feast down low, as the 76ers have scored 54.7 points in the paint per game over their last three.

What you need to know about the 76ers

Ever since injuries afflicted the Sixers, the team has played above expectations despite missing some of its best players. Philly is 7-1-1 against the spread over its last nine games, after beginning the year 5-7 ATS as a mostly healthy unit.

Joel Embiid returned on Monday after a four-game absence, and he resumed his MVP-caliber level of production with 30 points, eight boards, seven assists, two blocks and two steals. Tobias Harris has stepped up recently as he's put up 20 points per game over his last 10, compared to 13.4 PPG over his first nine contests. Both players should have more ease at scoring in the paint on Wednesday with Allen out as he leads the team in defensive rating and rebounds, while ranking second in blocks.

How to make Cavaliers vs. 76ers picks

The model has simulated 76ers vs. Cavaliers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the pick at SportsLine.

Who wins Cavaliers vs. 76ers? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks, and find out!