The Chicago Bulls and the Cleveland Cavaliers will face off in a Central Division clash at 8 p.m. ET Wednesday at the United Center. Chicago is 27-15 overall and 15-6 at home, while Cleveland is 27-18 overall and 15-9 on the road. The Cavaliers extended their winning streak to five games with a victory over Brooklyn on Monday, while Chicago has lost four straight.

Cleveland is favored by 2.5 points in the latest Bulls vs. Cavaliers odds from Caesars Sportsbook, while the over-under is set at 215. Before entering any Cavaliers vs. Bulls picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 14 of the 2021-22 NBA season on a stunning 56-30 roll on all top-rated NBA picks, returning over $2,200. Anyone following it has seen huge returns.

Now, the model has set its sights on Bulls vs. Cavaliers. You can head to SportsLine to see its picks. Here are several NBA betting lines for Cavaliers vs. Bulls:

  • Bulls vs. Cavaliers spread: Bulls +2.5
  • Bulls vs. Cavaliers over-under: 215 points
Featured Game | Chicago Bulls vs. Cleveland Cavaliers

What you need to know about the Bulls

Chicago will be looking to take advantage of a lone home game sandwiched between five road games. The Bulls are on a four-game losing streak following their 119-106 setback at Memphis on Monday. They are currently without a pair of starters in Zach LaVine and Lonzo Ball, who are both sidelined with knee injuries, while Javonte Green (adductor) and Derrick Jones Jr. (knee) are also out.

One of their best defensive players, Alex Caruso, is expected to return on Wednesday. He has not played since Dec. 20 due to injuries and the NBA's health and safety protocol. Small forward DeMar DeRozan leads Chicago with 25.6 points and 5.0 rebounds per game. The Bulls have won nine of their last 11 home games. 

What you need to know about the Cavaliers

Cleveland is red-hot coming into this game, winning each of its last five games. The Cavaliers won four consecutive road games and then added a 114-107 win against Brooklyn on Monday night. Point guard Darius Garland led the way with 22 points and 12 assists, scoring or assisting on eight of Cleveland's first 10 points in the fourth quarter. 

It was a team effort, though, as five other players finished in double figures. Cleveland has already notched one win over Chicago this season, picking up a 115-92 win on Dec. 8. The Cavaliers have covered the spread in 10 of their last 14 games against Eastern Conference opponents. New addition Rajon Rondo (hamstring) will not be available on Wednesday.

How to make Bulls vs. Cavaliers picks

The model has simulated Bulls vs. Cavaliers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Cavaliers vs. Bulls? And which side covers well over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its NBA picks.