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The San Antonio Spurs and the Memphis Grizzlies will face off in a Southwest Division clash at 8:30 p.m. ET on Wednesday at the AT&T Center. San Antonio is 18-30 overall and 9-15 at home, while Memphis is 32-17 overall and 15-8 on the road. The Grizzlies have won four of their last five head-to-head meetings against the Spurs. 

Memphis is favored by 4.5-points in the latest Spurs vs. Grizzlies odds from Caesars Sportsbook, while the over-under is set at 228.5. Before entering any Grizzlies vs. Spurs picks, you'll want to see the NBA predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 15 of the 2021-22 NBA season on a stunning 58-32 roll on all top-rated NBA picks, returning over $2,100. Anyone following it has seen huge returns.

Now, the model has set its sights on Spurs vs. Grizzlies. You can head to SportsLine to see its picks. Here are several NBA betting lines for Spurs vs. Grizzlies:

  • Spurs vs. Grizzlies spread: Spurs +4.5
  • Spurs vs. Grizzlies over-under: 228.5 points
Featured Game | San Antonio Spurs vs. Memphis Grizzlies

What you need to know about the Spurs

The Spurs made easy work of the Houston Rockets on Tuesday, picking up a 134-104 win. The matchup was all but wrapped up at the end of the third, as San Antonio had established a 105-74 advantage. The Spurs can attribute much of their success to point guard Dejounte Murray, who recorded a double-double with 19 points and 10 assists. 

San Antonio hit a season-best 57.4 percent of its attempts from the floor. The Spurs scored 82 points in the paint, which are the most of any NBA team this season. They have covered the spread at a 13-5 clip in their last 18 games against a Western Conference opponent. 

What you need to know about the Grizzlies

Memphis is heading to San Antonio for the second part of its four-game road trip after losing to Dallas on Sunday. The Grizzlies have lost two of their last three games, scoring a season-low 34 points in the first half against Dallas. Star guard Ja Morant led the team with 35 points and a career-high 13 rebounds. 

The Grizzlies knocked down just 4-of-24 of their attempts from the 3-point arc. Morant leads Memphis with 25.3 points per game, while small forward Dillon Brooks is scoring 18.4 points. The Grizzlies have covered the spread in 10 of their last 13 games. 

How to make Spurs vs. Grizzlies picks

The model has simulated Spurs vs. Grizzlies 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Grizzlies vs. Spurs? And which side of the spread hits 60 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its NBA picks.