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The Los Angeles Lakers visit the Philadelphia 76ers in a high-profile showdown on Thursday evening at Wells Fargo Center. The Lakers (24-24) are 9-12 on the road this season, while the Sixers (28-19) are 11-10 in their home building so far in 2021-22. Ben Simmons (personal), Seth Curry (ankle) and Shake Milton (back) are out for Philadelphia, with Danny Green (hip) questionable. Kendrick Nunn (knee) is out for Los Angeles, with LeBron James (knee) listed as questionable.

Philadelphia is listed as a four-point home favorite, and tip-off is scheduled for 7:30 p.m. ET. The total number of points Vegas thinks will be scored, or the Over-Under, is 217 in the latest Lakers vs. 76ers odds. Before you make any NBA predictions with the Lakers vs. 76ers match-up, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 15 of the 2021-22 NBA season on a stunning 58-32 roll on all top-rated NBA picks, returning over $2,100. Anyone following it has seen huge returns.

Now, the model has set its sights on Lakers vs. Sixers, and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA betting lines and trends for Sixers vs. Lakers:

  • Lakers vs. 76ers spread: 76ers -4
  • Lakers vs. 76ers over-under: 217 points
  • Lakers vs. 76ers money line: 76ers -190, Lakers +160
  • LAL: The Lakers are 10-11 against the spread in the road games
  • PHI: The 76ers are 8-13 against the spread in home games
Featured Game | Philadelphia 76ers vs. Los Angeles Lakers

Why the Lakers can cover

Los Angeles is formidable in multiple categories on both sides of the floor. The Lakers are in the top 10 of the NBA in field-goal accuracy at 46.5 percent, including 53.8 percent on 2-point shots. Los Angeles is in the top 10 in free-throw attempts, averaging 21.8 per game, and the Lakers are strongly above-average in assists (24.1 per game), fast-break points (15.3 per game) and points in the paint (47.7 per game). 

On defense, the Lakers allow 34.4 percent shooting from 3-point range while forcing 15.0 turnovers per game. Los Angeles is in the top seven in steals per game (8.2) and blocked shots per game (5.6), with the 76ers struggling in key categories on offense. Philadelphia is last in offensive rebound rate, with bottom-10 marks in 3-pointers per game and assists per game.

Why the 76ers can cover

Philadelphia has a solid defense, and this is also a strong matchup for the 76ers on that side of the court. The 76ers are allowing 109.0 points per 100 possessions this season, with opponents shooting 45 percent from the field and 34.6 percent from three-point range. Philadelphia ranks in the top 10 in steals (7.8 per game) and assists allowed (23.3 per game), with a top-five mark in blocked shots (5.7 per game). 

Los Angeles is just No. 23 on offense this season, battling all kinds of spacing issues. The Lakers are also No. 24 in the league in offensive rebound rate, with a bottom-10 mark in turnover prevention and the No. 27 mark in free throw accuracy. Philadelphia should also benefit from the Lakers' bottom-five marks in assists allowed and free throw attempts allowed on the defensive end.

How to make 76ers vs. Lakers picks

SportsLine's model is leaning over on the total, projecting 218 combined points. The model also says one side of the spread hits well over 50 percent of the time. You can only see the model's pick at SportsLine.

So who wins Lakers vs. 76ers? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.