The Los Angeles Lakers (22-22) host the Indiana Pacers (15-29) at 10:30 p.m. ET on Wednesday, Jan. 19 at Crypto.com Arena in Los Angeles. The Lakers are coming off a big 101-95 win over the Utah Jazz on Monday, while the Pacers are riding a four-game losing streak after falling 139-133 to the Los Angeles Clippers also on Monday.

The Lakers are favored by 4.5 points in the latest Lakers vs. Pacers odds from Caesars Sportsbook, and the over-under is set at 223.5. Before making any Pacers vs. Lakers picks, you need to see the NBA predictions and betting advice from the computer simulation model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 14 of the 2021-22 NBA season on a stunning 56-30 roll on all top-rated NBA picks, returning over $2,200. Anyone following it has seen huge returns.

Now, the model has set its sights on Lakers vs. Pacers, and just locked in its NBA picks and predictions. You can head to SportsLine to see its picks. Here are several NBA betting odds and lines for Lakers vs. Pacers:

  • Lakers vs. Pacers spread: Lakers -4.5
  • Lakers vs. Pacers over-under: 224 points
  • Lakers vs. Pacers moneyline: Lakers -200, Pacers +170
Featured Game | Los Angeles Lakers vs. Indiana Pacers

What you need to know about the Lakers

Los Angeles didn't have too much breathing room in their contest with the Utah Jazz on Monday, but they still walked away with a 101-95 victory. It was another big night for Los Angeles' small forward LeBron James, who had 25 points and seven assists along with seven rebounds.

James has played himself into the MVP discussion while keeping the Lakers alive in the Western Conference. Anthony Davis (knee) and Carmelo Anthony (back) remained sidelined for Los Angeles. The Lakers are 18-26 against the spread in 2021-22.

What you need to know about the Pacers

Meanwhile, Indiana was within striking distance but couldn't close the gap on Monday as they fell 139-133 to the Los Angeles Clippers. Point guard Duane Washington Jr. had a pretty forgettable game, finishing with ten points on 4-for-10 shooting in his 26 minutes on the court.

Domantas Sabonis is a double-double machine for Indiana. The power forward out of Gonzaga is averaging 18.9 points, 11.9 rebounds, and 4.7 assists per game this season. The Pacers are 3-17 on the road and 21-22-1 against the spread in 2021-22.

How to make Lakers vs. Pacers picks

The model has simulated Lakers vs. Pacers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the model's Pacers vs. Lakers pick at SportsLine.

So who wins Pacers vs. Lakers? And which side of the spread hits almost 60 percent of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.