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The San Antonio Spurs visit the Philadelphia 76ers for a cross-conference NBA battle on Friday evening. The Spurs bring a 15-22 record and an 8-12 road mark into the game, while the 76ers are 7-8 in home games, 21-16 overall and are on a five-game winning streak. Tyrese Maxey (protocols), Shake Milton (back) and Ben Simmons (personal) are out for Philadelphia, with Danny Green (calf) and Isaiah Joe (back) listed as questionable. Derrick WhiteDevin Vassell, Keldon JohnsonDoug McDermott and Thaddeus Young are out for San Antonio due to protocols.

The 76ers are listed as 7.5-point home favorites in Philadelphia, and tip-off is scheduled for 7 p.m. ET. The total number of points Vegas thinks will be scored, or the Over-Under, is 219 in the latest odds. Before you make any NBA predictions with the Spurs vs. 76ers match-up, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 12 of the 2021-22 NBA season on a stunning 50-27 roll on all top-rated NBA picks, returning almost $2,000. Anyone following it has seen huge returns.

Now, the model has set its sights on Spurs vs. Sixers, and just locked in its coveted picks and NBA predictions. You can head to SportsLine now to see the model's picks. Now, here are several NBA odds and betting lines for 76ers vs. Spurs:

  • Spurs vs. 76ers spread: 76ers -7.5
  • Spurs vs. 76ers over-under: 219 points
  • Spurs vs. 76ers money line: SA +250, PHI -320
  • San Antonio: The Spurs are 11-9 against the spread in road games
  • Philadelphia: The 76ers are 5-10 against the spread in home games
Featured Game | Philadelphia 76ers vs. San Antonio Spurs

Why the Spurs can cover

The Spurs have an intriguing offensive profile. San Antonio is No. 2 in the NBA in assists, averaging 28.2 per game, and the Spurs are in the top two in assist percentage (64.9 percent) and assist-to-turnover ratio (2.14). San Antonio is also shooting 46.7 percent from the floor, sixth in the NBA, and the Spurs are making 35.5 percent of three-point attempts. The Spurs produce 14.6 second-chance points per game, with top-six marks in fast break points (14.1 per game) and points in the paint (54.6 per game). 

On defense, the Spurs do a fantastic job on the margins, giving up only 10.2 fast break points and 19.2 free throw attempts per game. San Antonio is above-average in turnover creation, forcing 14.4 per game, and opponents average only 23.7 assists per game against the Spurs. In addition, Philadelphia is No. 28 in three-pointers and dead-last in the NBA in offensive rebound rate.

Why the 76ers can cover

Philadelphia's defense is in a favorable position against San Antonio. The 76ers are above-average in shooting efficiency allowed this season, ranking in the top 10 of the NBA in assists allowed at 23.1 per game. Philadelphia also allows opponents to produce only 20.6 free throw attempts per contest, and the 76ers wall off the rim in allowing only 45.0 points per game in the paint. On top of that, the 76ers are effective in creating havoc, ranking No. 2 in the NBA in blocked shots (5.9 per game) and firmly in the top 10 in steals (7.9 per game). 

San Antonio's offense is missing key pieces in this game, and the Spurs are clearly scuffling in a couple of areas. The Spurs are second-worst in the NBA in free throw attempts on offense, and San Antonio is also second-worst in three-pointers per game.

How to make Spurs vs. 76ers picks

SportsLine's model is leaning over on the total, with 14 players projected to score at least nine points. The model also says one side of the spread hits in well over 50 percent of simulations. You can only see the model's Sixers vs. Spurs pick at SportsLine.

So who wins 76ers vs. Spurs? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to find out which side of the Spurs vs. Sixers spread you need to jump on Friday, all from the model that has crushed its NBA picks, and find out.