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Vikings receiver Justin Jefferson has been lighting up the league, but Minnesota will face a top-10 defense when it hosts the Kansas City Chiefs in NFL Week 5. That is one of 12 games on the Week 5 NFL schedule on Sunday, a slate that offers plenty of wagering opportunities for NFL props. Jefferson leads the NFL in receiving yards with 543 and is averaging 99.4 per game over his three-plus seasons.  The Chiefs are allowing 190 passing yards per game (eighth in NFL), but the latest NFL prop bets list the over/under on Jefferson's receiving yards at a sky-high 104.5.

Vikings quarterback Kirk Cousins' passing yards total is 293.5 in the NFL player props, while Kansas City's Patrick Mahomes' number is 291.5. There is plenty of value in the many NFL props available in the Week 5 NFL odds. Before you make any NFL Week 5 prop bets on sites like PrizePicks, you need to check out the top NFL picks and NFL predictions from SportsLine NFL props expert Alex Selesnick.

Selesnick (aka PropStarz) specializes in NFL, MLB and NBA prop betting, where he implements a combination of research, statistical analysis and mathematical modeling.

The expert has been crushing his picks in all sports and was a highly profitable 42-28 on NFL prop picks in this column during the 2022 regular season. He is 23-29 on all NFL props plays for SportsLine this season. The expert also went 174-152 on MLB prop plays for SportsLine this season and 522-425 on NBA props over the past two seasons.

Now, after combing over the hundreds of available Week 5 NFL prop bets, PropStarz has found the value picks he loves. He's only sharing them at SportsLine

Top 2023 Week 5 NFL prop picks

One NFL Week 5 prop play PropStarz loves for Sunday is Titans running back Derrick Henry over 75.5 rushing yards. Indianapolis' defense ranks 23rd against the run, giving up 126 yards per game, and Henry has run all over them. The eighth-year Tennessee workhorse has topped 100 yards in seven of the past eight meetings. He also comes off his best game of the season, a 22-carry, 122-yard effort in a 27-3 victory against the Bengals in Week 4.

"The big man looked like vintage Henry last week," PropStarz told SportsLine. The expert points specifically to Henry's 29-yard touchdown run, when he "showed off his signature explosiveness" in breaking several tackles and outrunning the Bengals' defense. Henry is averaging 2.7 yards per carry, but is at 4.3 in the two games in which he topped 20 attempts. Henry needs the ball and should get it against the Colts, with the Titans' pass game struggling. You can see all of PropStarz's Week 5 NFL prop bets at SportsLine.

How to make 2023 NFL Week 5 prop bets and predictions

PropStarz has locked in several other confident Week 5 NFL prop picks. They include one running back to cruise past his rushing total and another to get into the end zone. You can only see these NFL prop picks over at SportsLine.

What are the best 2023 Week 5 NFL prop bets you can make and which running backs should you back? Visit SportsLine now to see the best NFL Week 5 prop bets, all from the expert who was 42-28 on his SportsLine prop plays in his NFL props article last season, and find out.