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The Buffalo Bills will try to continue their impressive start to the 2021 season with a road trip on Monday Night Football. Buffalo is 4-1 in 2021, including a road win over the Kansas City Chiefs in Week 5. The Bills face a strong opponent in the Tennessee Titans, led by running back Derrick Henry. Tennessee leads the AFC South at 3-2 and also won in Week 5, toppling the Jacksonville Jaguars.

Kickoff is at 8:15 p.m. ET in Nashville. Caesars Sportsbook lists the Bills as six-point road favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 53.5 in the latest Bills vs. Titans odds. Before you make any Titans vs. Bills picks or NFL predictions, you need to see what SportsLine's advanced computer simulation model has to say.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bills vs. Titans, and it just released its coveted picks and predictions. You can head to SportsLine now to see model's Titans vs. Bills picks. Now, here are several NFL odds and betting lines for Bills vs. Titans:

  • Bills vs. Titans spread: Bills -6
  • Bills vs. Titans over-under: 53.5 points 
  • Bills vs. Titans money line: Bills -270, Titans +220 
  • BUF: Bills are 4-1 against the spread this season 
  • TENN: Titans are 3-2 against the spread this season
Featured Game | Tennessee Titans vs. Buffalo Bills

Why Josh Allen and the Bills can cover

The Bills have forced more turnovers (15) than any team in the NFL and are forcing a turnover on a whopping 22.8 percent of defensive possessions. Buffalo leads the NFL in scoring defense (12.8 points allowed per game) and points allowed per drive (1.00), with the No. 1 mark in total defense, giving up only 251.8 total yards per game to opponents. The Bills are rock-solid against both the pass and run, leading the league in rushing touchdowns allowed (one).

Buffalo is also uber-elite in both third and fourth down situations, with opponents converting only 32.3 percent of third down attempts and a meager 22.2 percent of fourth down tries. The Bills lead the NFL in red zone defense, giving up a touchdown on only 35.7 percent of attempts inside the 20-yard line, and there is a path for Buffalo to put pressure on Tennessee quarterback Ryan Tannehill. No quarterback has been sacked as many times (20) as Tannehill this season, and the Bills have a deep bench of pass rush talent.

Why Derrick Henry and the Titans can cover

Derrick Henry led the NFL in rushing yards (640) after Week 5 and Henry also led the league with seven rushing touchdowns. He is exceedingly durable, leading the NFL in carries, and combines explosiveness with power and craft. With Henry in the middle of Tennessee's attack, the Titans are the No. 3 rushing offense, generating nearly 170 yards per game, and are averaging 4.9 yards per carry this season.

The Titans are also quite efficient as an overall offensive, ranking No. 3 in first downs with 127, and avoid turnovers, giving the ball away on only 12.5 percent of offensive possessions.

How to make Bills vs. Titans picks

SportsLine's model is leaning under on the point total, with no Bills rusher projected to reach 60 yards and the Titans projected to throw for fewer than 200 yards. The model also says one side of the spread hits in well over 60 percent of simulations. You can only get the model's strong Bills vs. Titans picks at SportsLiine.

So who wins Titans vs. Bills on Monday Night Football? And which side of the spread cashes in well over 60 percent of simulations? Visit SportsLine now to find out which side of the Titans vs. Bills spread you need to jump on, all from the model that has crushed its NFL picks, and find out.