Kyle Shanahan and the San Francisco 49ers will face Kliff Kingsbury and the Arizona Cardinals on Monday Night Football. The Cardinals won both matchups between the NFC West rivals last season, with the 49ers looking to return the favor. The game will take place at Estadio Azteca in Mexico City, the fourth-ever NFL game to be played in Mexico. Arizona is 4-6 overall and San Francisco is 5-4 overall on the heels of back-to-back wins.

Kickoff is at 8:15 p.m. ET in Mexico. Caesars Sportsbook lists the 49ers as 10-point favorites, while the over/under, or total number of points Vegas thinks will be scored, is 42.5 in the latest 49ers vs. Cardinals odds. Before you make any Cardinals vs. 49ers picks and NFL predictions, you need to see what SportsLine's top 49ers expert, Micah Roberts, has to say.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. He's also on a 13-3 roll on his last 16 picks involving the 49ers, making him the most well-qualified expert to pick Monday Night Football.

Now, Roberts has set his sights on 49ers vs. Cardinals and just locked in his picks and MNF predictions. You can head to SportsLine now to see his picks. Now, here are several NFL odds and betting lines for 49ers vs. Cardinals:

  • 49ers vs. Cardinals spread: 49ers -10
  • 49ers vs. Cardinals over/under: 42.5 points 
  • 49ers vs. Cardinals money line: 49ers -480, Cardinals +360
  • SF: 49ers are 4-5 against the spread this season 
  • AZ: Cardinals are 5-5 against the spread this season 
  • 49ers vs. Cardinals picks: See picks here
Featured Game | Arizona Cardinals vs. San Francisco 49ers

Why the 49ers can cover

The 49ers are in the top 10 in total offense, yards per drive, passing yards, and interception avoidance this season. San Francisco is also in the top five in net yards per pass attempt (7.2) and third down efficiency (45.6%), with the 49ers acquiring a dynamic star midseason in Christian McCaffrey. The All-Pro running back has 226 scrimmage yards and four total touchdowns in the last two weeks and joined a multi-faceted group of skill position weapons.

San Francisco is also facing a vulnerable Arizona defense that is allowing 25.8 points per game, third-worst in the NFL. The Cardinals are in the bottom 10 in total yards allowed, first downs allowed, completion percentage allowed, third down efficiency allowed, and red zone efficiency allowed. Opponents have 17 touchdown passes and only seven interceptions against Arizona's defense, and San Francisco's diverse attack is difficult to contain. See which team covers here.

Why the Cardinals can cover

Arizona's offense is averaging 23.0 points per game. Wide receiver DeAndre Hopkins has 36 catches in four games since returning from suspension and is a five-time Pro Bowl selection and three-time All-Pro. He is in the top three among active NFL players in career catches (825), receiving yards (10,977) and receiving touchdowns (70).

Arizona is above-average with 206 first downs on offense this season, and the turnover battle is key for the Cardinals. Kliff Kingsbury's team has only nine turnovers this season, a top-five mark in the NFL, and San Francisco has 13 turnovers, including seven lost fumbles, in only nine games. See which team covers here.

How to make 49ers vs. Cardinals picks

Roberts has analyzed this matchup and while we can tell you he's leaning Over on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Cardinals vs. 49ers on Monday Night Football in Mexico City? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Cardinals vs. 49ers spread to back, all from the expert who's 13-3 on Niners picks, and find out.