The Week 1 NFL schedule concludes with a Monday Night Football matchup between the Seattle Seahawks and Denver Broncos. This is one of the games that NFL fans instantly circled when the 2022 NFL schedule came out in May because it marks the debut for new Broncos quarterback Russell Wilson. Plus, in a storyline perfect for primetime, it comes at Lumen Field against the Seahawks, the franchise he played for from 2012 to 2021. Wilson was a nine-time Pro Bowl selection in Seattle and won Super Bowl XLVIII.

Kickoff from Lumen Field in Seattle is set for 8:15 p.m. ET. Denver is a seven-point favorite in the latest Seahawks vs. Broncos odds from Caesars Sportsbook, while the over/under for total points scored is 44. Before making any Broncos vs. Seahawks picks, be sure to see the NFL predictions and betting advice from SportsLine's Josh Nagel.

Nagel is a Nevada-based handicapper with more than 20 years of experience in the sports wagering industry. SportsLine's assistant managing editor has covered the wagering industry on a variety of platforms, and has won numerous sports handicapping contests. He has hit 56% of his NFL spread picks since the start of the 2017 season and has a documented 40-22 record on all SportsLine proposition-bet specials.

In addition, Nagel has gone 17-6 on his last 23 NFL picks involving the Seahawks, returning $1,040. Anyone who has followed him is way up.

Now, Nagel has set his sights on Seahawks vs. Broncos and locked in his NFL picks and predictions. You can head to SportsLine to see his picks. Here are several NFL odds and trends for Broncos vs. Seahawks:

  • Seahawks vs. Broncos spread: Denver -7
  • Seahawks vs. Broncos over/under: 44 points
  • Seahawks vs. Broncos money line: Denver -320, Seattle +250
  • DEN: Broncos are 5-1 against the spread in their last six September games
  • SEA: Seahawks are 16-7 ATS in their last 23 games as underdogs
  • Seahawks vs. Broncos picks: See picks at SportsLine
Featured Game | Seattle Seahawks vs. Denver Broncos

Why the Broncos can cover

Wilson has been one of the NFL's top quarterbacks for the past decade. Despite missing three games due to injury, Wilson still threw for more than 3,000 yards in 2021. He completed 259 of 400 passes (64.8 percent) for 3,113 yards and 25 touchdowns against just six interceptions.

Denver had a pair of running backs in Melvin Gordon and Javonte Williams who rushed for 900 or more yards and scored four or more touchdowns in 2021. Gordon played in 16 games and led the Broncos in rushing with 918 yards on 203 carries (4.5 average) and eight touchdowns. He had three explosive plays of 20 yards or more. Williams played in all 17 games, carrying 203 times for 903 yards (4.4 average) and four touchdowns. He had six plays of 20 or more yards.

Why the Seahawks can cover

Geno Smith will get the first crack at replacing Russell Wilson. Smith played relatively well in relief of Wilson last season after he went down with a finger injury in October. In three starts, Smith guided Seattle to a 3-0 record against the spread. He was extremely impressive in his final start against the Jaguars, completing 83.3% of his passes, throwing two touchdowns and running for another.

He has a talented receiving duo in DK Metcalf and Tyler Lockett. Seattle has one of the best home-field edges in the league and Lumen Field should be rocking due to Wilson's return. Seattle is 22-5 straight-up in home primetime games since 2010, so this could be a value spot catching 6.5 points.

How to make Broncos vs. Seahawks picks

Nagel has analyzed this matchup from every angle and while we can tell you he's leaning Under the total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and who to back, at SportsLine.

So who wins Broncos vs. Seahawks on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Broncos vs. Seahawks spread to back, all from the NFL expert who's 17-6 on picks involving Seattle, and find out.