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A close game could be in store when the Detroit Lions visit the Minnesota Vikings for an NFL North showdown during the Week 3 NFL schedule. The last three meetings between these rivals have been decided by two points, with the Vikings winning the first two before falling 29-27 at Detroit in Week 13 last season. The Lions are 6-point road underdogs in the latest Week 3 NFL odds at Caesars Sportsbook. Other Week 3 NFL spreads include Buffalo as a 5.5-point favorites against Miami and Green Bay as a 1.5-point underdog versus Tampa Bay. Which Week 3 NFL lines should you target with your Week 3 NFL bets? Before you make any Week 3 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.  

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 3. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 3 NFL picks at SportsLine

Top Week 3 NFL picks

After simulating every game 10,000 times, the model is high on the Cincinnati Bengals (-6) to win and cover against the New York Jets on Sunday. Cincinnati has suffered three consecutive close setbacks dating back to Super Bowl LVI, losing each contest by three points. The Bengals have yet to own a lead this season, but managed to rally back from deficits in each of their first two games, only to lose on field goals as time expired.

The Jets didn't take their first lead of 2022 until late in the fourth quarter of last Sunday's miraculous 31-30 win at Cleveland, moving ahead with 22 seconds remaining. Cincinnati looks to finally get in the win column, and the model has the Bengals covering the spread almost 60% of the time. See which other NFL parlay picks to make here.

How to make Week 3 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing a shocking team even though they were dominated last week. You can only see the model's NFL Week 3 best bets and parlay at SportsLine

What are the model's top Week 3 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 3 NFL best bets from a model on a 139-102 run on its top-rated picks, and find out.