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The No. 17 Southern California Trojans and the Arizona State Sun Devils are set to square off in a Pac-12 matchup at 8 p.m. ET on Wednesday at the Galen Center. The Trojans are 17-3 overall and 10-1 at home, while Arizona State is 7-9 overall and 2-2 on the road. USC has won six of the last 10 meetings between these two teams.

The Trojans are favored by 10-points in the latest USC vs. Arizona State odds from William Hill Sportsbook, and the over-under is set at 148.5. Before entering any Arizona State vs. USC picks, you'll want to see the college basketball predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on USC vs. Arizona State. You can head to SportsLine to see its picks. Here are several college basketball odds for USC vs. Arizona State:

  • USC vs. Arizona State spread: Trojans -10
  • USC vs. Arizona State over-under: 148.5 points

What you need to know about Southern California

USC didn't have too much trouble with the Washington State Cougars on the road this past Saturday as the Trojans won 76-65. USC's success was spearheaded by the efforts of guard Tahj Eaddy, who had 29 points, and forward Evan Mobley, who posted a double-double with 20 points and 11 rebounds in addition to six blocks. Mobley enters Wednesday's contest averaging 16.6 points and 9.0 rebounds per game. 

The Trojans have won six straight games and they are 5-0 against the spread in their last five outings. USC is also 5-0 ATS in its last five meetings against the Sun Devils. 

What you need to know about Arizona State

Meanwhile, Arizona State sure made it a nail-biter, but the Sun Devils managed to escape with a 75-73 victory over the Oregon State Beavers on Sunday. Four players on Arizona State scored in the double digits: Remy Martin (23), Alonzo Verge Jr. (15), Jalen Graham (14), and Holland Woods (10).

The Sun Devils are led by Martin on the offensive end of the floor. The senior guard is averaging 19.2 points, 4.0 assists and 2.6 rebounds per game. He's scored 23 or more points in four of his last five outings, and he'll need to have a big game on Wednesday if the Sun Devils want to pull off the upset on the road. 

How to make USC vs. Arizona State picks

The model has simulated USC vs. Arizona State 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Arizona State vs. USC? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.