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Notre Dame (4-4) and Indiana (8-2) will battle it out in a matchup at the 2021 Crossroads Classic on Saturday afternoon. The Fighting Irish came out victorious in their last game. They upset No. 21 Kentucky in a 66-62 final. The Hoosiers will look to secure their second straight win. On Dec. 12, Indiana defeated Merrimack 81-49. 

Tipoff is at 2:30 p.m. ET from Gainbridge Fieldhouse in Indianapolis. Caesars Sportsbook lists the Hoosiers as 4.5-point favorites in the latest Notre Dame vs. Indiana odds. The over-under for total points is set at 132.5. Before making any Indiana vs. Notre Dame picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven computer model

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Notre Dame vs. Indiana, and just locked in its picks and CBB predictions. You can head to SportsLine to see its picks. Now, here are several college basketball odds and betting lines for Indiana vs. Notre Dame:

  • Notre Dame vs. Indiana spread: Indiana -4.5
  • Notre Dame vs. Indiana over-under: 132.5 points
  • Notre Dame vs. Indiana money line: Indiana -200, Notre Dame +170
  • ND: Over is 5-1 in Fighting Irish last six neutral site games
  • IU: Hoosiers are 5-1 ATS in their last six games as a favorite

Why Indiana can cover

Junior forward Trayce Jackson-Davis has played lights out for the Hoosiers. He is averaging a team-high 19.3 points, 8.4 rebounds, and 3.4 blocks. The Indiana native is also shooting a team-best 61 percent from the field. Jackson-Davis has scored in double figures in nine of the 10 games he's played in. In a win against Marshall, he put a season-high 43 points with five rebounds and five blocks.

Redshirt senior forward Race Thompson averages 10.6 points along with 8.7 rebounds per game. Thompson has registered three double-doubles on the season so far. His best outing came in a loss to Syracuse. The Minnesota native stuffed the stat sheet and finished with 17 points, 12 rebounds and eight assists. 

Why Notre Dame can cover

The Fighting Irish upset No. 21 Kentucky 66-62 in their last matchup and had four players finish with double-digit points. Junior guard Dane Goodwin scored 14 points with six rebounds. He shot the ball well, finishing the game 5 of 9 from the floor. Freshman guard Blake Wesley also added 14 points, four rebounds, and three assists. The Illinois native knocked down two 3-pointers.

Junior guard Trey Wertz gave Notre Dame a must-needed spark off the bench. Wertz had 12 points, two assists, and hit two 3-pointers in the upset victory. Notre Dame couldn't be stopped in the paint. The Irish outscored the Wildcats 38-26 in that category. The Fighting Irish will look to build off this victory and secure their second consecutive win. 

How to make Indiana vs. Notre Dame picks

SportsLine's model is leaning over on the total, projecting the teams to combine for 141 points. The model also says one side of the spread hits in over 50 percent of simulations. You can only see the model's pick at SportsLine.

So who wins Notre Dame vs. Indiana? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the spread you need to jump on Saturday, all from the model that has crushed its college basketball picks, and find out.