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The last time either Oregon or Colorado swept the Pac-12 season series against the other was in the 2014-15 season when the Ducks took both regular season meetings. The sides meet for the second time this year on Thursday night at 10 p.m. in Boulder, after the Buffaloes took the victory in their first matchup on January 25. Colorado has lost four of its last five games, with its win against Oregon as the outlier, while the Ducks come into the matchup with revenge on their minds and wins in their last three away games.

The Ducks are favored by 2.5 points in the latest Colorado vs. Oregon odds from Caesars Sportsbook, and the over-under is set at 139. Before entering any Oregon vs. Colorado picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Colorado vs. Oregon. You can head to SportsLine to see its picks. Here are several college basketball odds for Oregon vs. Colorado:

  • Colorado vs. Oregon spread: Oregon -2.5
  • Colorado vs. Oregon over-under: 139 points
Featured Game | Colorado Buffaloes vs. Oregon Ducks

What you need to know about Colorado

Colorado looked like a much different team than its win against Oregon on Sunday, when it got blown out by Washington State, 70-43. The Buffaloes have lost two of their last seven games by at least 20 points, and have won just two games during that skid. The Buffs made just 28.6 percent of their attempts against the Cougars, and the best thing that could be said about the performance was Jabari Walker's 11 points on a 5-for-9 shooting night.

Something that has hampered Colorado over the last few games has been the absence of starting forward Tristan Da Silva. He has been out with an undisclosed issue that was originally thought to be a non-COVID illness, and his availability tonight is unknown. Although he isn't a prolific scorer, Colorado loses 9.2 points and 3.4 rebounds per game without him in the lineup. His last appearance came against Oregon, when he scored 15 points.

What you need to know about Oregon

Everything went Oregon's way against their rival, the Oregon State Beavers on Saturday in a 78-56 victory. Oregon got double-digit scores from four players: Guards Jacob Young (17), Will Richardson (15) and De'Vion Harmon (14), as well as forward Eric Williams Jr. (14). The win was their first action since their loss at home to Colorado.

The Ducks don't go overboard when it comes to shooting 3-pointers. Oregon averages just 20.6 attempts per game from beyond the arc, and hit 7-of-20 in their previous game against the Buffs. Without taking too many chances on shots from downtown, the Ducks have shot 47.3 percent this season, and have the best field-goal percentage in the Pac-12, as they've hit 47.9 percent of their shots in conference play. 

How to make Colorado vs. Oregon picks

The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

Who wins Colorado vs. Oregon? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks, and find out.