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A Pac-12 battle is on tap between the No. 16 Southern California Trojans and the Colorado Buffaloes at 7:30 p.m. ET on Thursday at the CU Events Center. Colorado is 12-4 overall and 9-1 at home, while the Trojans are 14-2 overall and 4-1 on the road. The Buffaloes have won seven straight meetings between these teams. 

The Trojans are favored by two points in the latest Colorado vs. USC odds from Caesars Sportsbook, while the over-under is set at 137. Before entering any USC vs. Colorado picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Colorado vs. Southern California. You can head to SportsLine to see its picks. Here are several college basketball odds for Southern California vs. Colorado:

  • Colorado vs. Southern California spread: USC -2
  • Colorado vs. Southern California over-under: 137 points

What you need to know about Colorado

Colorado bounced back from a loss to then-No. 6 Arizona with a 75-57 blowout at Arizona State over the weekend. The Buffaloes were hot from the perimeter, converting on 10 of their 25 3-point attempts. They have lost all three of their games against ranked opponents so far this season. 

Colorado should be able to neutralize Southern California's height, as the Buffaloes rank sixth nationally in defensive rebounding percentage. No one on their roster has lost to the Trojans during their career, as Colorado has won the last seven meetings between these teams. Sophomore forward Jabari Walker leads the Buffaloes with 13.1 points and 8.5 rebounds per game.  

What you need to know about Southern California

USC has now lost two of its last three games after going 13-0 in its first 13 contests. The Trojans came up short in a 79-69 final against Oregon last Saturday, marking their first home loss of the season. They are built to play in the altitude, as they have nine players averaging more than 10 minutes per game. 

Junior forward Isaiah Mobley leads the team with 15.3 points and 9.2 rebounds per game. Chevez Goodwin, Boogie Ellis and Drew Peterson are all scoring in double figures as well. The Trojans are the third-tallest team in college basketball and rank seventh in defensive field goal percentage. 

How to make Southern California vs. Colorado picks

The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins USC vs. Colorado? And which side covers over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.