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The Vanderbilt Commodores and the LSU Tigers will face off in an SEC clash at 7 p.m. ET Wednesday at Pete Maravich Assembly Center. LSU is 12-15 overall and 9-7 at home, while the Commodores are 15-12 overall and 4-5 on the road. These teams have split their last six matchups, with the home team winning all six times.

 The Commodores are favored by 2.5 points in the latest LSU vs. Vanderbilt odds from Caesars Sportsbook, and the over/under is set at 140. Before entering any Vanderbilt vs. LSU picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 16 of the season 71-42 on all-top rated college basketball picks this season, returning more than $1,700 for $100 players. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on LSU vs. Vanderbilt. You can head to SportsLine to see its picks. Here are several college basketball odds for Vanderbilt vs. LSU:

  • LSU vs. Vanderbilt spread: LSU +2.5
  • LSU vs. Vanderbilt over/under: 140 points
  • LSU vs. Vanderbilt money line: LSU +118, Vanderbilt -140
  • LSU vs. Vanderbilt picks: See picks here

What you need to know about LSU

LSU came up short against the South Carolina Gamecocks this past Saturday, falling 82-73. Despite the defeat, LSU got a solid performance out of guard Cam Hayes, who had 25 points in addition to eight boards. It was the 14th straight defeat for the Tigers, who dropped to 1-13 in conference play.

LSU's struggles can be pointed to the offensive end of the court as the team ranks last in the SEC in both field goal percentage and points per game. The team has also had unprecedented turnover from last year's squad that went to the NCAA Tournament as a No. 6 seed as just 7.3% of the scoring from last year returned to this year's unit. LSU has just two players averaging in double figures -- KJ Williams (16 PPG), who transferred from Murray State, and Adam Miller (11.4 PPG), who transferred from Illinois.

What you need to know about Vanderbilt

Meanwhile, Vanderbilt sure made it a nail-biter, but it managed to escape with a 67-65 victory over the Auburn Tigers this past Saturday. It was another big night for Vanderbilt's forward Liam Robbins, who dropped a double-double on 24 points and 12 rebounds.

The Commodores have experienced some offensive struggles of their own as they have only been able to knock down 41.7% percent of their shots, which is the 30th lowest field goal percentage in college basketball. A bright spot has been the play of Robbins who is a matchup nightmare as a 7-footer who also hits 35% of his 3-point attempts. On the other end of the court, Robbins ranks fourth in the NCAA with 3.0 blocks per game.

How to make Vanderbilt vs. LSU picks

The model has simulated LSU vs. Vanderbilt 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the pick at SportsLine.

So who wins Vanderbilt vs. LSU? And which side of the spread hits well over 60% of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.