No. 15 Oregon (10-3) and No. 14 Oklahoma (10-2) will battle it out in the 2021 Valero Alamo Bowl on Wednesday night. Both squads look to redeem themselves after picking up a loss in their last matchups. Oregon fell to No. 10 Utah in the Pac-12 championship game as the Utes blew out the Ducks 38-10. Meanwhile, Oklahoma couldn't knock off its in-state rival Oklahoma State as the Sooners lost to the Cowboys 37-33.

Kickoff is at 9:15 p.m. ET from the Alamodome. The Sooners are seven-point favorites, while the over-under or total number of points Vegas thinks will be scored, is 64 in the latest Oregon vs. Oklahoma odds from Caesars Sportsbook. Before locking in any Oklahoma vs. Oregon picks, be sure to check out the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also enters the third week of the 2021-22 college football bowl season on a 43-30 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oregon vs. Oklahoma, and just revealed its coveted picks and predictions. You can head to SportsLine to see all of the model's college football bowl game picks. Here are several college football odds and trends for Oklahoma vs. Oregon:

  • Oregon vs. Oklahoma spread: Oklahoma -7
  • Oregon vs. Oklahoma over-under: 64 points 
  • Oregon vs. Oklahoma money line: Oklahoma -280, Oregon +230
  • OU: Sooners are 4-0 ATS in their last four neutral site games as a favorite 
  • ORE: Ducks are 9-4 ATS vs. a team with a winning record
Featured Game | Oklahoma Sooners vs. Oregon Ducks

Why Oklahoma can cover

Sophomore receiver Marvin Mims is the leading pass-catcher for the Sooners and has reeled in a team-high 30 receptions for 648 yards with four scores. Mims is the best deep threat on this squad and is averaging 21.6 yards per reception, which tops the Big 12 and ranks fourth in the nation. The Texas native has logged three games with more than 100 yards receiving.

In the win against Texas Tech, Mims caught four passes for 135 yards with two scores. Senior receiver Michael Woods II was third on the team with 381 receiving yards and should see more targets with second-leading receiver Jadon Haselwood transferring to Arkansas. Woods, who transferred from the Razorbacks this year, had a team-high of eight grabs for 86 yards vs. West Virginia early in the year. This duo of Woods and Mims for Oklahoma has the talent to light it up on Wednesday night.

Why Oregon can cover

Senior quarterback Anthony Brown was second in the Pac-12 with 2,683 passing yards while tossing 15 touchdowns. Brown also has the athleticism to make plays with his legs. He was second on the team with 637 rushing yards along with nine scores. The New Jersey native logged more than 300 total scrimmage yards in four contests during the regular season. 

Junior running back Travis Dye was one of the top rushers in the Pac-12. He was third in the conference in rushing yards (1,118) with 15 rushing scores. Dye scored a rushing touchdown in 10 of the 13 games played. His best outing came in a win against Washington as the California native had 28 carries for 211 yards and a score. The ground game for Ducks has been explosive and can cause problems for the Sooners' defense. 

How to make Oregon vs. Oklahoma picks

SportsLine's model is leaning under on the point total, projecting the teams to combine for 59 points. The model also says one side of the spread hits in almost 60 percent of simulations. You can only see the model's Alamo Bowl pick at SportsLine.

So who wins Oregon vs. Oklahoma? And which side of the Alamo Bowl spread hits in almost 60 percent of simulations? Visit SportsLine now to see which side of the Oklahoma vs. Oregon spread you need to jump on, all from the model that has crushed its college football picks, and find out.