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After six consecutive losing seasons, the Colorado Buffaloes are looking to turn things around under new coach Deion Sanders as they battle the Big 12 perennial power TCU Horned Frogs in a non-conference season opener on Saturday. Colorado, which finished 1-11 last year, including 1-8 in the Pac-12, has not had a winning season since going 10-4 overall and 8-1 in the Pac-12 South in 2016. TCU, which was 13-2 overall and 9-0 in the Big 12 in 2022, has had a winning season in 13 of the past 17 years. The Horned Frogs lost to Georgia in last year's national championship.

Kickoff from Amon G. Carter Stadium in Fort Worth, Texas, is set for noon ET. TCU averaged 455 yards per game in 2022, while Colorado averaged 281.3. The Horned Frogs are favored by 21 points in the latest Colorado vs. TCU odds, while the over/under for total points scored is 63.5. Before making any TCU vs. Colorado picks, be sure to check out the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Colorado vs. TCU and just revealed its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for TCU vs. Colorado:

  • Colorado vs. TCU spread: TCU -21
  • Colorado vs. TCU over/under: 63.5 points
  • Colorado vs. TCU money line: Colorado +727, TCU -1180
  • COL: The Buffaloes have gone over the total in nine of their last 11 games
  • TCU: The Horned Frogs were 10-4-1 ATS last season 
  • Colorado vs. TCU picks: See picks at SportsLine 

Why TCU can cover

Despite the loss of several talented players to graduation, the Horned Frogs get a boost on offense with a number of key transfers, including junior wide receiver JoJo Earle and junior running back Trey Sanders, both who played at Alabama a year ago. Earle has 24 career receptions for 303 yards (12.6 average) and two touchdowns. He saw action in six games last season, catching three passes for 38 yards and a score in a 30-6 win over No. 11 Mississippi State. He also scored a touchdown in a 49-26 win at No. 20 Arkansas, catching a 22-yard score.

In three seasons at Alabama, Sanders finished with 528 yards rushing on 116 carries (4.6 average) and three touchdowns. Last season, he was limited to 14 carries for 80 yards (5.7 average) and one TD. His best year was in 2021, when he rushed 72 times for 314 yards (4.4 average) and two touchdowns, including one against Miami in the Chick-Fil-A Kickoff Game, a 44-13 Crimson Tide win. He also had six receptions for 55 yards. See which team to pick here

Why Colorado can cover

The Buffaloes will get an influx of talent, including junior transfer quarterback Shedeur Sanders. The son of coach Deion Sanders, Shedeur played the past two seasons under his father at Jackson State. In two seasons there, he completed 613 of 896 passes (68.4%) for 6,963 yards, 70 touchdowns and just 14 interceptions for a 156.3 rating. He also rushed 188 times for 156 yards and nine touchdowns.

Also expected to make a big impact is senior transfer Xavier Weaver. The wide receiver, who played his first four seasons at South Florida, racked up 116 career receptions for 1,735 yards (15 average) and eight touchdowns for the Bulls. Last year, Weaver caught 53 passes for 718 yards (13.5 average) and six TDs. He had three games with 100 yards or more, and two games with two touchdowns. See which team to pick here.

How to make Colorado vs. TCU picks

SportsLine's model is leaning Under on the point total, projecting the teams to combine for 56 points. The model also says one side of the spread has all the value. You can only see the model picks at SportsLine.

So who wins Colorado vs. TCU, and which side of the spread has all the value? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of almost $2,500 on its top-rated college football spread picks, and find out.