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The Seattle Seahawks are reeling as they head into Sunday Night Football with a number of key injuries. Most obvious is that Russell Wilson (finger) will be sidelined for the first time in his career, paving the way for Geno Smith to start. Also missing in Seattle's backfield is running back Chris Carson, who was placed on injured reserve with a neck injury this week. Carson's backup, Alex Collins, was serviceable in his place with 72 yards from scrimmage last week. Collins is expected to be among the most popular NFL DFS picks on Sunday. 

As for Smith, the veteran quarterback has been a journeyman backup since leaving New York and is getting his first real opportunity as a starter since then. Can he hold down the fort vs. the Steelers and provide value for your NFL DFS lineups? Or should you look elsewhere for production when crafting your NFL DFS strategy? Before locking in your NFL DFS picks for Steelers vs. Seahawks, be sure to check out the NFL DFS advice, player rankings, stacks and top daily Fantasy football picks from SportsLine's Mike McClure

McClure is a legendary professional DFS player with almost $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments last season.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

Now, McClure has turned his attention to the Steelers vs. Seahawks NFL DFS slate and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for Seahawks vs. Steelers

One of McClure's top NFL DFS picks for Sunday Night Football is Steelers quarterback Ben Roethlisberger. Big Ben had his best game in over a year in Week 5 as his 120.9 passer rating was his second-highest since the 2018 season. Roethlisberger threw for 253 yards and two scores against the league's No. 2 scoring defense in Denver.

That's a great sign for his fortunes in Week 6 as he goes from facing Denver's elite defense to Seattle's league-worst defense. The Seahawks rank dead last in yards allowed and have also allowed the third-most passing yards in the NFL this season. Seattle has allowed at least 300 passing yards in four straight games despite many of those opposing QBs not being amongst the elite. Roethlisberger seemed to get back on track last week and should have continued success on Sunday Night Football.

Part of McClure's optimal NFL DFS strategy also includes rostering Seahawks wide receiver Tyler Lockett. No wideout got out to a hotter start to the season than Lockett, who posted 12 receptions for 278 yards and three touchdowns through the first two games. Since then, he's posted a 13-112-0 stat line over the last three weeks but has a great opportunity on Sunday Night Football.

Pittsburgh has allowed the third-most Fantasy points to opposing receivers this season as its once-ferocious defense isn't quite as fearsome. The Steelers have allowed seven receiving TDs to opposing wideouts over the last three weeks alone, and they've allowed numerous players to go off as those seven scores came from five different players. Wilson's injury just means Seattle is expected to be trailing quite often in this game and that would present more opportunities for Lockett. Lock him in your NFL DFS lineups and look for a big return against the Steelers. 

How to set NFL DFS lineups for Steelers vs. Seahawks

McClure is also targeting an undervalued player who is set to explode for huge numbers on Sunday night. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here

So who is Mike McClure putting in his optimal NFL DFS lineups for Sunday Night Football? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with nearly $2M in winnings, and find out.