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Division foes collide when the Chicago Cubs (22-30) host the St. Louis Cardinals (30-22) in the first matchup of a doubleheader on Saturday afternoon. The Cubs had their three-game win streak halted, falling 14-5 to St. Louis on Friday. On the flip side, St. Louis is looking to keep the momentum up. The Cardinals have gone 6-2 in their last eight games. Johan Oviedo is starting for St. Louis, while the Cubs will start Matt Swarmer

First pitch is set for 1:20 p.m. ET. Caesars Sportsbook lists Chicago as the slight -115 favorite (risk $115 to win $100) in the latest Cardinals vs. Cubs odds. The over-under for total runs scored is set at nine. Before making any Cubs vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 48-31 roll on top-rated MLB money-line picks through eight weeks, returning over $1,100 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Cubs vs. Cardinals and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines and trends for Cardinals vs. Cubs:

  • Cardinals vs. Cubs money line: St. Louis -105, Chicago -115
  • Cardinals vs. Cubs run-line: Chicago +1.5 (-170)
  • Cardinals vs. Cubs over-under: 9 runs
  • Cardinals vs. Cubs tickets: See tickets at StubHub
  • STL: Cardinals are 4-1 in their last five overall
  • CHC: Over is 12-2 in Cubs last 14 Saturday games

Why you should back the Cardinals

The Cardinals have been one of the best hitting teams in the league thus far. St. Louis is filled with plenty of dynamic hitters and playmakers. Infielder Brendan Donovan is a smooth batter with the lineup who owns solid pitch recognition. Donovan has a batting average of .296 with one homer and 10 RBIs. On June 1, he went 2-for-4 with two singles.

Infield Tommy Edman is a patient, switch-hitter in the lineup. Edman can make consistent contact and is a base-stealing threat. The 27-year-old is tied for second in the majors in stolen bases (14) along with his teammate Harrison Bader. Edman's batting average is .281 with four home runs and 22 RBIs. In his last contest, he went 3-for-5 with three singles and three runs scored. 

Why you should back the Cubs

Shortstop Nico Hoerner owns good judgment of the strike zone with solid instincts at the plate. Hoerner knows how to make constant contact and spread the ball all across the yard. The 25-year-old also plays stout defense and has sound fundamentals. Hoerner's batting average is .281 with three home runs and 16 RBIs.

Third baseman Patrick Wisdom plays good defense and is a stable defender in the corner. The 30-year-old has displayed home-run power with run-producing qualities. Wisdom is tied for 12th in the majors in home runs (12) and tied for 20th in RBIs (31). In his last outing, he went 2-for-4 with a three-run homer. 

How to make Cardinals vs. Cubs picks

SportsLine's model is leaning over on the total, projecting 10.5 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Cubs vs. Cardinals? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.