The New York Yankees (52-19) host the Houston Astros (44-26) in the third game of their series on Saturday afternoon. New York had a two-game win streak halted on Friday, when it fell 3-1 to the Astros. Both teams sit atop their respective divisions and own the two best records in the American League. Gerrit Cole (6-1, 3.14 ERA) will be starting for the Yankees. Cristian Javier (4-3, 3.07 ERA) is on the mound for Houston.

The first pitch is set for 1:05 p.m. ET. Caesars Sportsbook lists New York as the -175 favorite (risk $175 to win $100) in the latest Astros vs. Yankees odds, while Houston is the +155 underdog. The over-under for total runs is set at eight. Before making any Yankees vs. Astros picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Astros vs. Yankees, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Yankees vs. Astros:

  • Yankees vs. Astros moneyline: New York -175, Houston +155
  • Yankees vs. Astros run-line: New York -1.5 (+120)
  • Yankees vs. Astros over-under: 8 runs
  • Yankees vs. Astros tickets: See tickets at StubHub
  • HOU: Astros are 14-3 in their last 17 during Game 3 of a series
  • NYY: Yankees are 10-2 in their last 12 vs. American League West
Featured Game | New York Yankees vs. Houston Astros

Why you should back the Yankees

Outfielder Giancarlo Stanton is a big-time slugger with a powerful swing for New York. Stanton has the strength and bat speed to drive the ball into any gap. The four-time All-Star can play either outfield position and he owns a rocket of an arm. Stanton is hitting .246 with 16 home runs and 46 RBIs. He's recorded a home run in back-to-back games.

Second baseman DJ LeMahieu knows how to make consistent contact and has good awareness of the strike zone. LeMahieu displays a good combination of speed and athleticism on the diamond. The three-time All-Star is hitting .260 with six home runs with 29 RBIs. In his last contest, he was 2-for-5 with two singles. 

Why you should back the Astros

Second baseman Jose Altuve is a steady contributor for Houston. Altuve owns quick hands with good pop in his swing. The seven-time All-Star is a slick infielder with smooth reaction times. He has a batting average of .273 with 13 home runs and 24 RBIs. On June 23, he went 3-for-4 with two doubles and two runs scored.

Outfielder Kyle Tucker possesses fast hands with serious home-run power. Tucker has an effortless swing that generates plenty of bat speed. The 25-year-old is second on the team in home runs (14) and RBIs (48) with a batting average of .262. On June 24, he went 1-for-4 with a three-run homer. 

How to make Astros vs. Yankees picks

SportsLine's model is leaning over on the total, projecting 8.8 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Yankees vs. Astros? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.