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The Detroit Pistons will take on the Boston Celtics at 7:30 p.m. ET Friday at TD Garden. Boston is 40-27 overall and 23-11 at home, while the Pistons are 18-48 overall and 7-26 on the road. These teams have already met three times over the last five weeks with Boston winning two but with Detroit covering in all three.

Boston is favored by 13.5 points in the latest Celtics vs. Pistons odds from Caesars Sportsbook, and the over-under is set at 215.5. Before entering any Pistons vs. Celtics picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters Week 20 of the 2021-22 NBA season on a stunning 74-47 roll on all top-rated NBA picks, returning almost $2,100. Anyone following it has seen huge returns.

Now, the model has set its sights on Celtics vs. Pistons. You can head to SportsLine to see its picks. Here are several NBA betting lines for Pistons vs. Celtics:

  • Celtics vs. Pistons spread: Celtics -13.5
  • Celtics vs. Pistons over-under: 215.5 points

What you need to know about the Celtics

Boston didn't have too much trouble with the Charlotte Hornets on the road on Wednesday as it won 115-101. It was another big night for Boston's small forward Jayson Tatum, who shot 6-for-9 from beyond the arc and finished with 44 points and five rebounds.

Tatum had scored 54 points in his previous game and is now averaging a career-high of 26.8 PPG which ranks eighth in the NBA. Tatum's eight highest-scoring games this year have all resulted in Celtics victories as his scoring is a barometer to team success. But Boston is a complete team as it has an elite scorer in Tatum while also ranking third in the NBA in defensive efficiency and points allowed.

What you need to know about the Pistons

Meanwhile, Detroit was within striking distance but couldn't close the gap on Wednesday as it fell 114-108 to the Chicago Bulls. The Pistons outscored the Bulls in each of the first three quarters but were then outscored by 13 points in the final frame. Shooting guard Cade Cunningham (22 points) was the top scorer for Detroit.

The Pistons have only been able to knock down 42.6 percent of their shots, which is the second-lowest field goal percentage in the league. Detroit also ranks second-worst with a 32.3 3P percentage and second-to-last with 103.6 PPG. However, Cunningham has put his name into Rookie of the Year contention as the No. 1 pick has five straight games with at least 20 points while also averaging 8.0 rebounds and 5.4 assists over that stretch.

How to make Pistons vs. Celtics picks

The model has simulated Celtics vs. Pistons 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Pistons vs. Celtics? And which side of the spread hits in almost 70 percent of simulations? Visit SportsLine now to find out, all from the model that has crushed its NBA picks.