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The Miami Heat will take on the Philadelphia 76ers at 8 p.m. ET on Saturday at FTX Arena. Miami is 42-22 overall and 21-7 at home, while Philadelphia is 39-23 overall and 21-10 on the road. It's a battle between the top two teams in the Eastern Conference standings, but Miami will be shorthanded with Kyle Lowry (personal) already ruled out and Jimmy Butler (toe) looking questionable.

However, both teams have covered in four of their last five games entering Saturday and the Heat have won and covered in two of the last three head-to-head matchups with the Sixers. Miami is favored by two points in the latest Heat vs. 76ers odds from Caesars Sportsbook and the over-under is set at 221. Before entering any 76ers vs. Heat picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters Week 19 of the 2021-22 NBA season on a stunning 71-44 roll on all top-rated NBA picks, returning over $2,100. Anyone following it has seen huge returns.

Now, the model has set its sights on Heat vs. Sixers. You can head to SportsLine to see its picks. Here are several NBA betting lines for Sixers vs. Heat

  • Heat vs. 76ers spread: Heat -2
  • Heat vs. 76ers over-under: 221 points
Featured Game | Miami Heat vs. Philadelphia 76ers

What you need to know about the 76ers

The 76ers didn't have too much room to spare against the Cleveland Cavaliers on Friday, but they still walked away with a 125-119 victory. The win came about thanks to a strong surge after the first quarter to overcome a 43-30 deficit. Philadelphia's point guard Tyrese Maxey looked sharp as he shot 5-for-6 from downtown and finished with 33 points and five assists.

James Harden also had 25 points and 11 assists in the win and Joel Embiid had 22 points and nine rebounds. Philadelphia is unbeaten in the four games since Harden entered the lineup after being acquired from the Nets and the Sixers have won seven of their last eight overall.

What you need to know about the Heat

Meanwhile, even if it wasn't a dominant performance, Miami beat the Brooklyn Nets 113-107 on Thursday. Miami's center Bam Adebayo dropped a double-double on 30 points and 11 rebounds, while also dishing out six assists. Adebayo is averaging 19.2 points and 10.3 rebounds per game and he could be carrying a heavy load again with Lowry out and Butler ailing.

The Heat rank top seven in the NBA in offensive rating (113.1) and defensive rating (108.3) but primary ball-handling and distribution could be an issue with Lowry and possibly Butler out. Gabe Vincent, Tyler Herro and even Adebayo will have to initiate offense if both are out.

How to make 76ers vs. Heat picks

The model is leaning under on the total and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins Heat vs. 76ers? And which side of the spread has all the value? Visit SportsLine now to find out, all from the model that has crushed its NBA picks.