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The Los Angeles Lakers (16-16) play host to the San Antonio Spurs (12-18) at 10:30 p.m. ET on Thursday, December 23 at the Staples Center in Los Angeles. The Lakers fell to the Phoenix Suns 108-90 on Tuesday night, extending their losing streak to three games. The Spurs, meanwhile, are coming off an impressive 116-92 victory over the Los Angeles Clippers on Monday night.

The Lakers are favored by one point in the latest Lakers vs. Spurs odds from Caesars Sportsbook, and the over-under is set at 224. Before making any Spurs vs. Lakers picks, you need to check out the NBA predictions and betting advice from the computer simulation model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 10 of the 2021-22 NBA season on a stunning 46-23 roll on all top-rated NBA picks, returning almost $1,900. Anyone following it has seen huge returns.

Now, the model has set its sights on Lakers vs. Spurs, and just revealed its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and betting lines for Lakers vs. Spurs:

  • Lakers vs. Spurs spread: Lakers -1
  • Lakers vs. Spurs over-under: 224 points
  • Lakers vs. Spurs moneyline: Los Angeles -125, San Antonio +105

What you need to know about the Spurs

The Spurs made easy work of the Los Angeles Clippers on Monday and carried off a 116-92 win. The contest was all but wrapped up at the end of the third, by which point San Antonio had established a 92-65 advantage. It was another big night for their point guard Dejounte Murray, who posted a triple-double on 24 points, 13 assists, and 12 rebounds.

The Spurs have seven players averaging double-digit points per game, led by Murray (18.1), Keldon Johnson (15.0), Derrick White (14.1), and Jakob Poeltl (12.2). Unlike most teams, the Spurs have a relatively clean injury report. San Antonio is 17-13 against the spread this season.

What you need to know about the Lakers

Meanwhile, the Lakers ended up a good deal behind the Phoenix Suns when they played on Tuesday, losing 108-90. Small forward Talen Horton-Tucker had a memorable game, but not in the way you want to be remembered: he finished with only three points on 1-for-13 shooting in his 31 minutes on the court.

The Lakers will be short-handed in this matchup with several players in COVID-19 protocols and star forward Anthony Davis nursing a knee injury. LeBron James (abdomen) is listed as day-to-day, but early reports suggest he'll play tonight. The Lakers are 12-20 against the spread this year.

How to make Lakers vs. Spurs picks

The model has simulated Lakers vs. Spurs 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You can only see the model's Lakers vs. Spurs pick at SportsLine.

So who wins Spurs vs. Lakers? And which side of the spread hits in almost 70 percent of simulations? Visit SportsLine now to see which side of the Lakers vs. Spurs spread you need to jump on Thursday, all from the model that has crushed its NBA picks, and find out.