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The Dallas Mavericks will take on the Detroit Pistons at 8:30 p.m. ET on Wednesday at the American Airlines Center. The Mavericks are 30-26 overall and 13-14 at home, while Detroit is 18-40 overall and 7-24 on the road. The Pistons have won six of the last 10 head-to-head matchups and are 5-4-1 against the spread during that span.

So far this season, the Pistons are 30-24-4 against the spread while the Mavericks are 26-30 against the number. However, with the much more talented roster, Dallas is favored by 10.5-points in the latest Mavericks vs. Pistons odds from William Hill Sportsbook, and the over-under is set at 218. Before entering any Pistons vs. Mavericks picks, you'll want to see the NBA predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times, and it has returned over $9,200 in profit on its top-rated NBA picks over the past two-plus seasons. The model is up over $1,200 on its top-rated picks this season, and dating back to last year, it entered Week 18 of the 2020-21 NBA schedule on a stunning 96-60 roll on top-rated NBA picks against the spread. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Mavericks vs. Pistons. You can head to SportsLine to see its picks. Here are several NBA betting lines for Mavericks vs. Pistons:

  • Mavericks vs. Pistons spread: Mavericks -10.5
  • Mavericks vs. Pistons over-under: 218 points
  • Mavericks vs. Pistons money line: Mavericks -600, Pistons +450

What you need to know about the Mavericks

Dallas received a tough blow on Sunday as the Mavericks fell 121-107 to the Sacramento Kings. Dallas' defeat came about despite a quality game from Luka Doncic, who had 37 points in addition to eight boards and three blocks. The 22-year-old superstar is averaging 28.6 points, 8.7 assists and 7.9 rebounds per game this season, all while shooting an impressive 48.6 percent from the floor.

Kristaps Porzingis had a tough night in Sunday's loss, shooting just 3-for-14 from the floor and finishing with just nine points. It will be interesting to see if Porzingis is in the lineup on Wednesday night with the Mavericks scheduled to play the Lakers on Thursday. The 25-year-old with a history of knee issues has traditionally been held out from at least one game of back-to-backs and the Lakers are another playoff team in the Western Conference.

What you need to know about the Pistons

Meanwhile, it was a close one, but on Monday Detroit sidestepped the Cleveland Cavaliers for a 109-105 victory. Center Isaiah Stewart was a standout for Detroit, posting a double-double with 18 points and 16 rebounds along with three blocks. Saddiq Bey also had a big night with 20 points and six made 3-pointers.

The two rookies will need to carry a large load again on Wednesday with fellow rookie Killian Hayes (injury management) expected to miss tonight's contest. Hayes had nine assists in the win over Cleveland so who steps up to handle point guard responsibilities will be key. Frank Jackson had 20 points off the bench in the win and would seem to be the logical replacement despite playing on a two-way contract.

How to make Mavericks vs. Pistons picks

The model has simulated Mavericks vs. Pistons 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Mavericks vs. Pistons? And which side of the spread hits in well over 60 percent of simulations? Visit SportsLine now to see which side of the Pistons vs. Mavericks spread to jump on, all from the model that is on an incredible roll.