The Detroit Lions went from 6-10 in 2010 to 10-6 in 2011, and quarterback Matthew Stafford took NFL Comeback Player of the Year honors. Now, he squares off against Cincinnati's Joe Burrow, the 2021 Comeback Player of the Year, in Super Bowl 56 on Sunday.  The two quarterbacks have been neck-and-neck with each other during the 2022 NFL playoffs, with Stafford taking the slight edge in total passing yards, completion percentage, and touchdown passes. Burrow has also been the most-sacked quarterback in the NFL playoff bracket with 12, while Stafford has been brought down just five times.

When is the Super Bowl 2022? Kickoff is at 6:30 p.m. ET on Sunday. Los Angeles is a 4.5-point favorite in the latest 2022 Super Bowl odds from Caesars Sportsbook, while the over-under is 48.5. Before locking in any 2022 Super Bowl picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters the 2022 Super Bowl on an incredible 137-97 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in four confident NFL best bets for Super Bowl LVI. If you successfully parlay its picks, you'd be looking at a massive payout of around 12-1. You can only see the model's Super Bowl 2022 picks at SportsLine

Top 2022 Super Bowl picks

After simulating every snap of Super Bowl LVI 10,000 times, the model is backing Cincinnati running back Joe Mixon to score a touchdown in the game at -111 odds. Mixon might not have had as strong of a case as Burrow to win Comeback Player of the Year, but his rebound after playing just six games last year has been remarkable. His production in the NFL playoffs has been steady, but he finished with his highest total carries (21) and yards (88) in his most recent postseason performance against Kansas City in the AFC Championship Game.

The Rams only needed to contend with 20 rush attempts by San Francisco in the NFC Championship Game, but surrendered just under four yards per carry to Tampa Bay's Leonard Fournette the previous week in their divisional round win. Fournette scored twice in that game, and the Bucs lost by just three points. For the Bengals to stand a chance in the Super Bowl, Mixon must factor into their offense, and the SportsLine model projects Mixon to get into the end zone in the majority of its simulations.

How to make 2022 Super Bowl parlays

The model locked in Super Bowl 56 picks and says one side of the spread cashes well over 50 percent of the time. You can only see the model's 2022 Super Bowl best bets and Rams vs. Bengals parlay at SportsLine

What are the model's top picks for Super Bowl LVI? And which other NFL picks should you target for a massive 12-1 payout? Visit SportsLine now to see the Super Bowl best bets from a model on a 137-97 run on its top-rated picks, and find out.