The Indianapolis Colts brought in quarterback Philip Rivers to help them get back to the NFL Playoffs. Now, they must get past the NFL's hottest team when they visit the Buffalo Bills on Saturday in the 2021 NFL Playoffs. Rivers has led one of the league's top 10 offenses in total yards and scoring, while the defense has been just as strong as the Colts (11-5) have won six of their last eight games. The Bills (13-3) have won nine of their last 10 games behind a high-powered offense led by quarterback Josh Allen.

Kickoff is set for 1:05 p.m. ET. William Hill Sportsbook lists Buffalo as a 6.5-point favorite in its latest Colts vs. Bills odds, while the over-under is 51.5. Before making any Bills vs. Colts picks or NFL predictions, be sure to check out the latest NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 23-13 on top-rated NFL picks this season, returning well over $800. The model also enters the 2021 NFL Playoffs on an incredible 119-77 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up. 

Now, the model has broken down Colts vs. Bills. You can head to SportsLine to see the picks. Here are the NFL odds and trends for Bills vs. Colts:

  • Colts vs. Bills spread: Buffalo -6.5
  • Colts vs. Bills over-under: 51.5
  • Colts vs. Bills money line: Indianapolis +245, Buffalo -290
  • Colts: RB Jonathan Taylor has rushed for 741 yards and seven TDs over the past six games
  • Bills: QB Josh Allen has 15 touchdown passes over the past five games

Why the Bills can cover

Buffalo has covered eight straight games, the longest streak in the NFL since 2018, and has won its last six by double-digits. Quarterback Josh Allen leads the league's No. 2 offense in scoring (31.3 points per game) and total yards (396.4). The third-year pro ranks fifth in the NFL with 4,544 yards, has thrown 37 TD passes, and also rushed for 421 yards. He faces a Colts defense that is 20th in the NFL against the pass (241.6 yards per game).

The home team has covered the spread in five straight meetings between these teams, and receiver Stefon Diggs leads the NFL in receptions (127) and yards (1,535). The defense is led by a secondary that features All-Pro corner Tre'Davious White (three interceptions, two fumble recoveries). The unit has forced 26 turnovers, third-most in the league.

Why the Colts can cover

Over the past three seasons, underdogs are 11-1 against the spread in Wild Card games, and Rivers is leading an offense that scores 28.2 points (ninth in NFL) and averages 378.1 yards (10th). He has more than 4,000 passing yards for the 12th time in his 17 seasons and 23 TD passes.

Rivers was part of offseason upgrades that included rookie running back Jonathan Taylor, who has rushed for 1,169 yards and 11 TDs, and receiver Michael Pittman (501 yards). 

DeForest Buckner is among the additions who have made a difference on the other side of the ball, notching 9.5 sacks for the Colts, who are 4-1 against the spread in their last five road games. He also helps anchor a unit that ranks second against the run (90.5 yards per game).

How to make Colts vs. Bills picks

SportsLine's model is leaning Under on the total, with the model suggesting the defenses will make plenty of impact plays. It also says one side of the spread hits in more than 50 percent of simulations, and you can only get the pick here. 

So who wins Bills vs. Colts on Saturday in the NFL Playoffs 2021? And which side of the spread cashes more than 50 percent of the time? Visit SportsLine right now to see which side of the Bills vs. Colts spread to back, all from the advanced model on a 119-77 run on NFL picks.