Get ready for an AFC South battle as the Indianapolis Colts and the Jacksonville Jaguars will face off at 4:25 p.m. ET on Sunday at TIAA Bank Field. The Colts snapped a four-game losing streak in Week 16. The Jaguars have lost six of their last seven games. Jacksonville is 5-10 overall and 2-5 at home, while Indianapolis is 7-8 overall and 2-5 on the road. Indianapolis is favored by 3.5 points in the latest Jaguars vs. Colts odds, while the over-under is set at 43. Before entering any Colts vs. Jaguars picks, you'll want to see the NFL predictions from the computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on its top-rated NFL picks since its inception four-plus years ago. It has nailed its recent top-rated NFL picks, entering Week 17 of the 2019 NFL schedule on a strong 33-22 run that dates back to last season. It's also on an incredible 95-65 roll on top-rated NFL picks that dates back to the 2017 season. The model ranked in the Top 10 on NFLPickWatch the past three years on straight-up NFL picks and beat more than 96 percent of CBS Sports office pool players last season. Anyone who has followed it is way up.

Now, it has simulated Jaguars vs. Colts 10,000 times and the results are in. We can tell you that the model is leaning under, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

Jacksonville took a 24-12 defeat against Atlanta on Sunday. Chris Conley led the Jaguars with five catches for 56 yards and a TD. Leonard Fournette rushed for 71 yards on 15 carries. 

Meanwhile, Indianapolis made easy work of Carolina on Sunday in a 38-6 win. Nyheim Hines became the first NFL player in seven years to score on two punt returns in the same game. Marlon Mack rushed 16 times for 95 yards and one score and topped the 1,000-yard mark for the first time. The Colts can avoid their second losing season in three years with a win over the Jaguars. 

The Jaguars ended up a good deal behind the Colts when the two teams met in November, losing 33-13. 

So who wins Colts vs. Jaguars? And which side of the spread has all the value? Visit SportsLine now to find out which side of the Jaguars vs. Colts spread you need to jump on Sunday, all from the model that has crushed its NFL picks.