Dobbins suffered a torn Achilles in Baltimore's 25-9 win, head coach John Harbaugh confirmed after the game.
Dobbins was helped to the locker room by members of the Ravens' training staff with 9:55 left in the third quarter. He left the game after a five-yard run that helped set up Justice Hill's short touchdown run on the next play.
Hill and Gus Edwards will handle the workload in the Ravens' backfield in Dobbins' absence.
The former Ohio State standout had 22 yards and a score on eight carries prior to getting injured. Injuries have plagued Dobbins since his second season in Baltimore. He missed the entire 2021 season after suffering a knee injury in the preseason. Dobbins missed 10 games last season after enduring another knee injury.
When healthy, Dobbins has been an effective starting running back. He averaged 6.0 yards per carry during his rookie season and 5.7 yards per carry last year. In 23 games, Dobbins has rushed for 1,325 yards and 11 touchdowns with a 5.9 yards per carry average.