NFL Week 16 kicks off with a Thursday Night Football matchup between Matthew Stafford and the Los Angeles Rams and Derek Carr and the New Orleans Saints. Kickoff at SoFi Stadium in Los Angeles is set for 8:15 p.m. ET. This showdown DFS slate will feature several Pro Bowl caliber players and two of the league's better defenses. Wide receivers Cooper Kupp, Puka Nacua, and Chris Olave will all be popular NFL DFS picks on TNF. Should you build your NFL DFS stacks and NFL DFS lineups around the wide receiver position? Or would it make more sense to target a running back like Alvin Kamara or Kyren Williams? Before making any NFL DFS picks for Rams vs. Saints on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor.
Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who cashed big all season in 2022, has covered the NFL and college football for over a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.
Kaylor hit on epic NFL DFS picks all season in 2022. He was all over Travis Kelce's four-touchdown performance against the Raiderson Monday Night Football, Kirk Cousins' 460-yard, four-TD performance on Thanksgiving Day, and T.J. Hockenson's 13 catches for 109 yards and two touchdowns in Week 15.
This year, Kaylor has been all over players like Justin Jefferson (11-159), D'Andre Swift (175-1), DeVonta Smith (4-132-1), T.J. Hockenson (7-66-2), D.J. Moore (8-230-3), David Montgomery (121-3), Ja'Marr Chase (12-141, 11-149-1), Alvin Kamara (12-91, 76), Jordan Addison (7-123-2), Jahmyr Gibbs (152-1, 5-37), Javonte Williams (79, 3-31-1), Dak Prescott (331-4), CeeDee Lamb (12-116-1), DK Metcalf (6-143-3), and Aidan O'Connell (248-4) in single-game slates. Anyone who followed his picks cashed in big.
Now, Kaylor has turned his attention to Rams vs. Saints on Thursday Night Football Week 16 and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.
Top NFL DFS picks for Rams vs. Saints on TNF
One of Kaylor's favorite NFL DFS picks for Week 16 TNF is Los Angeles quarterback Matthew Stafford. The 35-year-old signal caller remains one of the top passers in the game, and has been on an absolute tear over the last month. In the Rams' last four games, Stafford has thrown 12 touchdowns and only one interception, and Kaylor expects his strong play to continue on TNF.
"The Saints have one of the better defenses in the NFL, and they are limiting opposing offenses to only 185.4 passing yards per game. Still, I like this spot for Stafford, especially since he enters this matchup firing on all cylinders. The Rams have quietly built one of the top groups of pass catchers in the NFL, and I expect Stafford to have another big game in prime time on Thursday night," Kaylor told SportsLine.
Part of Kaylor's TNF DFS strategy also includes rostering Saints running back Alvin Kamara. The five-time Pro Bowl selection remains one of the most dynamic offensive players in the NFL, and New Orleans has made a concerted effort to get him plenty of touches this season. Kamara enters this matchup with 630 rushing yards and five touchdowns on the ground, and 68 receptions for 466 yards and a score through the air.
"Alvin Kamara remains one of the most explosive players in the league, and offensive coordinator Pete Carmichael Jr. has done an excellent job of getting him plenty of touches. The Rams are strong against the run, but Kamara's ability as a receiver makes him incredibly difficult to contain. I expect him to have another game with 15 or more targets on Thursday night," Kaylor said. You can see the rest of Kaylor's NFL DFS picks here.
How to build NFL DFS lineups for Rams vs. Saints on TNF
Kaylor is also targeting another undervalued player who could explode for huge numbers for Thursday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor's TNF DFS picks, at SportsLine.
So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Thursday Night Football, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament, and find out.
