Last year, Darnold played in 12 games for the Panthers, starting 11 and compiling a 4-7 mark. In that time, he threw nine touchdowns and 13 interceptions with a passer rating of 71.9.
This puts Mayfield, who started against the Baltimore Ravens last week, back on the sidelines. Mayfield was the team's quarterback in Weeks 1-5, . He played again in Week 9 and started last week in a loss to the Ravens.
The Panthers are 1-5 in games started by Mayfield this season. He has 57.8 completion percentage this season and has thrown six touchdowns and just as many interceptions.
Carolina is currently 3-8 and last in the NFC South.