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The two best primetime quarterbacks of all-time square off when Josh Allen and the Buffalo Bills host Aaron Rodgers and the Green Bay Packers on Sunday Night Football. Entering Sunday's game, the 26-year-old Allen has the best passer rating (108.6) among all quarterbacks with at least 300 pass attempts in primetime games since 1970. The 38-year-old Rodgers ranks second (106.5). Sunday's game pits two teams heading in opposite directions. The Bills (5-1) own the best record in the AFC, while the Packers (3-4) have lost three in a row.

Kickoff is set for 8:20 p.m. ET. Buffalo is a 10.5-point favorite in the latest Packers vs. Bills odds from Caesars Sportsbook, while the Over/Under for total points scored is 47. Before making any Bills vs. Packers picks or Week 8 NFL predictions of your own, you need to see what SportsLine NFL expert R.J. White has to say.

White, a Fantasy and gambling editor for CBS Sports, consistently crushes picks against-the-spread and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He's also gone a whopping 53-19-1 on his last 73 picks involving the Packers, meaning he's well-qualified for this selection. 

Now, he has locked in on Bills vs. Packers and just locked in his picks and NFL Week 8 predictions. You can head to SportsLine now to see White's picks. Here are the NFL odds and betting lines for Packers vs. Bills:

  • Packers vs. Bills spread: Buffalo -10.5 
  • Packers vs. Bills Over/Under: 47 points 
  • Packers vs. Bills money line: Buffalo -550, Green Bay +400 
  • BUF: Bills lead the league in total offense (440.8 yards per game) 
  • GB: Packers are 16-2 in their last 18 primetime games 
  • Packers vs. Bills picks: See picks here

Why the Bills can cover

Buffalo has the No. 1 ranked defense in the league. The Bills lead the league in scoring defense (13.5 points per game), total defense (281.5 yards per game) and rush defense (76.2). They also are tied for third in takeaways (13).

That defense will face a Green Bay offense that has struggled this season. The Packers rank 23rd in the league in scoring offense (18.3) and 20th in total offense (331.6). Over the team's three-game losing streak, Green Bay has averaged just 17.7 points and 270.3 yards per game. See which team to pick here.

Why the Packers can cover

Green Bay's defense has been stingy against the pass this season. The Packers are allowing just 168.9 passing yards per game, which is the best in the league. They've limited opponents to fewer than 100 passing yards twice this season, against the Bears (48 yards) and Jets (99). Led by the pass defense, Green Bay gives up just 308.4 total yards per game, which ranks seventh in the league.

In addition, the Packers have a disruptive force in Rashan Gary. The 6-foot-5, 277-pound edge rusher leads the team in sacks (six) and tackles for loss (seven) this season. He is one of five players this season with five-plus sacks, five-plus tackles for loss and 10-plus quarterback hits. See which team to pick here.

How to make Packers vs. Bills picks

White has analyzed this matchup from every angle, and while we can tell you he's leaning Under on the point total, he has also discovered a crucial x-factor that makes one side of the spread a must-back. You can only find out what it is, and see the rest of White's picks, at SportsLine.

Who wins Bills vs. Packers on Sunday Night Football? And what critical factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Bills vs. Packers spread you should jump on, all from the top NFL expert who's an amazing 53-19 on picks involving the Packers.