The NFC North-leading Minnesota Vikings will vie for their seventh consecutive win when they visit the AFC East-best Buffalo Bills on Sunday during the Week 10 NFL schedule. Thanks to its longest winning streak since an eight-game run in 2017, Minnesota owns a 4 ½-game lead in the division with a 7-1 record, its best eight-game start since 2009. The Vikings are 8-6 all-time against the Bills, but have lost four of their last five meetings. Buffalo is a 3.5-point favorite against Minnesota in the latest Week 10 NFL odds at Caesars Sportsbook. Which Week 10 NFL lines should you target with your Week 10 NFL bets? Before you make any Week 10 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 10. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 10 NFL picks at SportsLine.

Top Week 10 NFL picks

After simulating every game 10,000 times, the model is high on the Tennessee Titans (-3) to cover the spread against the Denver Broncos. The Titans boast the NFL's leading rusher, Derrick Henry, who has gained 870 yards and is averaging 108.8 per game. The two-time rushing champion has posted five consecutive 100-yard performances and recorded 903 scrimmage yards since Week 3, the most in the league during that span.

Denver has not had the success it expected when it acquired nine-time Pro Bowler Russell Wilson from Seattle during the offseason. The 33-year-old quarterback has a 59% completion percentage, a 3:2 touchdown-to-interception ratio, and an 83.5 passer rating during his first year with the Broncos, putting him on pace to post career worsts in each category. That is one reason the Titans are covering the spread in almost 60% of simulations. See which other NFL parlay picks to make here.

How to make Week 10 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that has a chance to win outright. You can only see the model's NFL Week 10 best bets and parlay at SportsLine

What are the model's top Week 10 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 10 NFL best bets from a model on a 151-108 run on its top-rated picks, and find out.