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The 12th-ranked Duke Blue Devils will look to extend their series win streak against the Louisville Cardinals to four games when they meet in an ACC matchup on Tuesday. The Blue Devils (13-4, 4-2 ACC), who have won six of the past 10 meetings, defeated Louisville 79-62 in their last matchup on Feb. 20, 2023. The Cardinals (6-12, 1-6 ACC), who have lost three straight and 9 of 11, are 4-4 against Duke all-time in games played in Louisville. The Blue Devils hold a 13-9 edge all-time against the Cardinals.

Tip-off is set for 7 p.m. ET from the KFC Yum! Center in Louisville, Ky. The Blue Devils are 14-point favorites in the latest Duke vs. Louisville odds from SportsLine consensus, while the over/under for total points scored is 149.5. Before making any Louisville vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division I college basketball game 10,000 times. It enters Week 12 of the 2023-24 season on a 114-73 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 19-5 start on top-rated spread picks this season. Anyone following has seen huge returns.

Now, the model has set its sights on Duke vs. Louisville. You can head to SportsLine to see the picks. Here are the latest betting trends and lines for Louisville vs. Duke:

  • Duke vs. Louisville spread: Duke -14
  • Duke vs. Louisville over/under: 149.5 points
  • Duke vs. Louisville money line: Duke -1199, Louisville +733
  • DUKE: The Blue Devils have hit the game total under in 10 of their last 14 road games (+5.60 units)
  • LOU: The Cardinals have hit the team total over in 20 of their last 31 games (+7.20 units)
  • Duke vs. Louisville picks: See picks at SportsLine

Why Duke can cover

Sophomore center Kyle Filipowski has been red hot of late, bettering his season average in each of the last three games. For the year, he averages 18.2 points, 8.6 rebounds, 2.9 assists, 1.9 blocks and 1.2 steals in 30.2 minutes. He has six double-doubles in 2023-24, including a 30-point and 13-rebound performance in an 84-79 win over Georgia Tech on Jan. 13. In Saturday's loss to Pitt, he scored 19 points and had five rebounds and two assists.

Sophomore guard Tyrese Proctor, who is one of three captains on the team, is coming off an 11-point and five-rebound effort in the loss to Pittsburgh. He scored a career-high 22 points on 7 of 11 (63.6%) shooting and was 6 of 6 from the free throw line against La Salle in a 95-66 win on Nov. 21. He ranks second in the ACC and 21st nationally in assist-to-turnover ratio at 3.24. See who to back at SportsLine.

Why Louisville can cover

Sophomore guard Mike James has carried the bulk of the scoring load for the Cardinals this year. In 18 games, all starts, he is averaging 14.1 points, 5.6 rebounds and 1.3 assists in 31.9 minutes of action. He is coming off a 16-point and four-rebound performance in the loss at Wake Forest. He scored a season-high 26 points in an 80-71 win at Miami on Jan. 10.

Also averaging double-digit scoring for Louisville is sophomore guard Skyy Clark. The transfer from Illinois is in his first season with the Cardinals and has made 18 starts. In 33.9 minutes of play, he is averaging 13.6 points, 3.1 rebounds, three assists and one steal. He has reached double-digit scoring in 13 games, including a season-high 29 in a 90-84 overtime win over New Mexico State on Nov. 26. See who to back at SportsLine.

How to make Duke vs. Louisville picks

The model has simulated this matchup 10,000 times and the results are in. The model is leaning Under the total, and it also says one side of the spread hits in over 60% of simulations. You can only see the picks at SportsLine.

So who wins Duke vs. Louisville, and which side of the spread hits over 60% of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that is on a 19-5 roll on its top-ranked college basketball picks, and find out.