An ACC matchup will get underway when the Syracuse Orange (9-9) travels to take on the No. 6 Duke Blue Devils (14-3) on Saturday afternoon. Syracuse defeated Clemson 91-78 in its last game. Duke is looking to bounce back after being upset in its last outing. Florida State beat the Blue Devils 79-78 in overtime on Jan. 18. 

Tipoff is set for noon ET. The latest Duke vs. Syracuse odds from Caesars Sportsbook list the Blue Devils as 11.5-point favorites, while the over-under for total points is set at 154. Before making any Syracuse vs. Duke picks, you need to check out the college basketball predictions and betting advice from the SportsLine Projection Model

The model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of more than $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Duke vs. Syracuse, and just revealed its picks and CBB predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and trends for Syracuse vs. Duke:

  • Duke vs. Syracuse spread: Duke -11.5
  • Duke vs. Syracuse over-under: 154 points
  • Duke vs. Syracuse: Duke -700, Syracuse +475
  • DUKE: The Blue Devils are 10-6 against the spread this season
  • SYR: The Orange are 9-9 against the spread this season 
Featured Game | Duke Blue Devils vs. Syracuse Orange

Why Duke can cover

Freshman forward Paolo Banchero has been great for the Blue Devils. He leads the team in scoring (18.1), rebounds (7.6) while shooting 51 percent from the field. Banchero has scored more than 20 points in six matchups. He has also recorded three double-doubles thus far. The Washington native put up a fight in the overtime loss to Florida State. Banchero finished with 20 points, 12 rebounds and seven assists.

Sophomore center Mark Williams has been an anchor for Duke. He is leading the ACC in blocks (3.4) while logging 9.6 points and 6.6 rebounds. Williams is an amazing rim protector, recording at least six blocks in four matchups. The Virginia native had a monster performance in the victory over NC State. Williams had 19 points, 11 rebounds and a season-high eight blocks. 

Why Syracuse can cover

Senior guard Buddy Boeheim is logging a team-best 19.2 points, 3.7 rebounds and 3.7 assists per game. Boeheim has scored 20-plus in five of his last 10 games. The New York native has also hit at least two 3-pointers in nine straight matchups. In the win over Clemson, Boeheim dropped 25 points, five rebounds and two steals.

His brother Jimmy Boeheim is also a solid contributor to this team. He is averaging 14.2 points and 6.4 rebounds per game. The senior forward tallied a double-double in his last game. Boeheim had 13 points and 10 boards. Junior guard Joseph Girard III is logging 13.9 points while knocking down a team-best 45 percent of his 3-point attempts. His best game this season came against Miami (FL). Girard III had 26 points while shooting 7-for-12 from deep. 

How to make Syracuse vs. Duke picks

SportsLine's model is leaning under on the total. It also says one side of the spread is hitting in well over 50 percent of the time. You can only get the model's pick at SportsLine.

So who wins Duke vs. Syracuse? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up more than $2,400 on its top-rated college basketball spread picks over the last five-plus years, and find out.