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The No. 10 Michigan State Spartans and the Nebraska Cornhuskers are set to square off in a Big Ten matchup at 7 p.m. ET on Wednesday at the Jack Breslin Student Events Center. The Spartans are 12-2 overall and 6-0 at home, while Nebraska is 6-8 overall and 0-2 on the road. Michigan State is now on a seven-game winning streak following its win over Northwestern on Sunday. 

The Spartans are favored by 15.5 points in the latest Michigan State vs. Nebraska odds from Caesars Sportsbook, while the over-under is set at 148.5. Before entering any Nebraska vs. Michigan State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Michigan State vs. Nebraska. You can head to SportsLine to see its picks. Here are several college basketball odds for Nebraska vs. Michigan State:

  • Michigan State vs. Nebraska spread: Michigan State -15.5
  • Michigan State vs. Nebraska over-under: 148.5 points

What you need to know about Michigan State

Michigan State is now riding a seven-game winning streak following a comeback effort against Northwestern on Sunday. The Spartans trailed by 13 points, but they were able to erase the deficit and put together a late run to seal the win. Leading scorer Gabe Brown scored 15 of his 20 points in the second half, knocking down a huge 3-pointer in the final minute. 

Michigan State shot just 1 of 10 from 3-point range in the first half, but it connected on 6 of 13 attempts following intermission. The Spartans have a rivalry game against Michigan on deck, so they will be looking to avoid a letdown performance on Wednesday night. They have now covered the spread in four of their last five games. 

What you need to know about Nebraska

Nebraska came up short against Ohio State on Sunday, falling 87-79 in overtime. The Cornhuskers led by five points in the final minute of regulation, but they missed two important free throws down the stretch to open the door for Ohio State. A silver lining for Nebraska was the play of forward Derrick Walker, who recorded a double-double with 15 points and 10 rebounds. 

This will be Nebraska's first road game since it traveled to then-No. 18 Auburn on Dec. 11. Freshman guard Bryce McGowens leads the Cornhuskers with 15.8 points and 5.9 rebounds per game, while senior guard Alonzo Verge Jr. is scoring 15.6 points and dishing out 5.8 assists. Nebraska is winless in its last eight games against Michigan State. 

How to make Michigan State vs. Nebraska picks

The model has simulated Michigan State vs. Nebraska 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Nebraska vs. Michigan State? And which side covers well over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.