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The Colorado Buffaloes will take on the No. 12 Tennessee Volunteers at 6 p.m. ET on Tuesday at Thompson-Boling Arena. Tennessee will be making its season debut after several early cancellations because of the coronavirus pandemic and Colorado is off to a perfect 2-0 start with wins over South Dakota and Kansas State. The Buffaloes covered in both of those wins but are just 3-9 against the spread in their last 12 games dating back to last season. 

Meanwhile, Tennesse is just 4-10 against the spread in its last 14 home games. The Volunteers are favored by 5.5 points in the latest Tennessee vs. Colorado odds from William Hill Sportsbook and the over-under is set at 138.5. Before entering any Colorado vs. Tennessee picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,700 for $100 players on its top-rated college basketball picks against the spread. It's also off to a fast start in the 2020-21 season, going 5-1 on all its top-rated picks and returning over $400. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Tennessee vs. Colorado. You can head to SportsLine to see its picks. Here are several college basketball odds for Colorado vs. Tennessee:

  • Tennessee vs. Colorado spread: Tennessee -5.5
  • Tennessee vs. Colorado over-under: 138.5 points
  • Tennessee vs. Colorado money line: Tennessee -250, Colorado +205

What to know about the Colorado Buffaloes

The Buffaloes have been off since their Nov. 27 win over Kansas State, but Tad Boyle's squad looked solid in a 76-58 win as five-point favorites. McKinley Wright IV had 24 points, five rebounds and five assists in the win and Colorado won the turnover battle 16-8.

Wright has now topped 20 points in both of Colorado's games and the fourth-year starter has scored 1,414 points already in his career. Tulsa transfer Jeriah Horne is averaging 10.0 points and 5.0 rebounds off the bench and freshman Jabari Walker has also produced 9.5 points and 4.5 rebounds off the Colorado bench. 

What to know about the Tennessee Volunteers

Tennessee welcomes back most of their production from a season ago with the exception of Jordan Bowden and also add Sacred Heart transfer E.J. Anosike, Oregon transfer Victor Bailey, five-star Keon Johnson and five-star Jaden Springer to the mix.

The Volunteers have the ability to go as many as 13 deep and one of Rick Barnes' toughest jobs early in the season will be paring that rotation down. Defending SEC Defensive Player of the Year Yves Pons and second-team All-SEC forward John Fulkerson also give Tennessee experience to lead from the front.

How to make Tennessee vs. Colorado picks

The model has simulated Tennessee vs. Colorado 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Tennessee vs. Colorado? And which side of the spread cashes in almost 70 percent of simulations? Visit SportsLine now to see which side of the Colorado vs. Tennessee spread to jump on Tuesday, all from the advanced model that is up almost $2,700 on its top-rated college basketball spread picks over the past four-plus years, and find out.