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The No. 18 Tennessee Volunteers will take on the Ole Miss Rebels at 7 p.m. ET on Wednesday at Thompson-Boling Arena. The Volunteers are 9-3 overall on the season, while the Rebels are 8-4 in 2021-22. Tennessee has won five of the last six games in the series and has covered the spread four times during that span.

However, Ole Miss did win the last meeting outright as a 3.5-point underdog last February and the Rebels have now covered two of three against Tennessee. The Volunteers are favored by 16.5 points in the latest Tennessee vs. Ole Miss odds from Caesars Sportsbook, and the over-under is set at 133.5. Before entering any Ole Miss vs. Tennessee picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Tennessee vs. Ole Miss. You can head to SportsLine to see its picks. Here are several college basketball odds for Ole Miss vs. Tennessee:

  • Tennessee vs. Ole Miss spread: Tennessee -16.5
  • Tennessee vs. Ole Miss over-under: 133.5 points
Featured Game | Tennessee Volunteers vs. Ole Miss Rebels

What you need to know about Tennessee

The Volunteers are coming off a 73-68 loss at the hands of the Alabama Crimson Tide last Wednesday where Tennessee led in the final minute but couldn't seal the deal. Olivier Nkamhoua had 15 points and nine rebounds in the defeat while Santiago Vescovi had 13 points before fouling out.

Tennessee was playing without freshman standout Kennedy Chandler and sixth-year senior John Fulkerson in that game because both were in COVID-19 protocols. However, both players have cleared protocols now and should play a big role on Wednesday against Ole Miss.

What you need to know about Ole Miss

Ole Miss will be making its first appearance on the court since Dec. 21 when it loss to Samford 75-73. Daeshun Ruffin had 17 points off the bench in the loss but shot just 6-of-18 from the floor in doing so. Jarkel Joiner had 15 points and four assists as well and is averaging 14.8 points per game to lead the Rebels.

The Rebels limited the Volunteers to just 35.6 percent shooting in a 52-50 victory last season and Kermit Davis' squad will be hoping to stymie a Tennessee offense that has been up-and-down throughout the season. The Volunteers have been held to less than 40 percent shooting in three of their last five games.

How to make Ole Miss vs. Tennessee picks

The model has simulated Tennessee vs. Ole Miss 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Tennessee vs. Ole Miss? And which side hits over 60 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.