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The No. 6 Villanova Wildcats will take on the Syracuse Orange at 9 p.m. ET Tuesday at Madison Square Garden as part of the Jimmy V Classic 2021. Villanova is 6-2 while 'Cuse is 5-3. These former Big East rivals last played each other in 2014 in which Nova prevailed by five points.

The Wildcats are favored by eight points in the latest Syracuse vs. Villanova odds from Caesars Sportsbook, and the over-under is set at 143.5. Before entering any Villanova vs. Syracuse picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Syracuse vs. Villanova. You can head to SportsLine to see its picks. Here are several college basketball odds for Villanova vs. Syracuse:

  • Syracuse vs. Villanova spread: Syracuse +8
  • Syracuse vs. Villanova over-under: 143.5 points
Featured Game | Syracuse Orange vs. Villanova Wildcats

What you need to know about Syracuse

The Florida State Seminoles typically have all the answers at home, but this past Saturday the Orange proved too difficult a challenge. 'Cuse came out on top in a nail-biter against FSU, sneaking past 63-60. Four players on Syracuse scored in the double digits: guard Joseph Girard III (16), forward Cole Swider (16), forward Jimmy Boeheim (13), and center Jesse Edwards (11).

The Orange have an above-average offense, but they have really struggled on the defensive end this season. Their defensive rating of 107.8 ranks 327th of 358 Division I teams and Syracuse has given up the second-most 3PMs per game in college basketball. Jim Boeheim's squad is led by his two sons as Buddy Boeheim leads the team in scoring while Jimmy Boeheim ranks third in scoring.

What you need to know about Villanova

Meanwhile, everything went the Wildcats' way against the Saint Joseph's Hawks this past Saturday as they made off with an 81-52 victory. Villanova's guard Collin Gillespie did his thing and shot 5-for-7 from beyond the arc and finished with 23 points. Nova was on fire from deep as it knocked down 52 percent of its 25 three-point attempts.

Gillespie has bounced back from a knee injury which ended his season early last year. The 2020-21 Big East Player of the Year is averaging a career high of 17.8 points and is shooting 46.9 percent from beyond the arc. The Wildcats are also getting a nice contribution from junior Justin Moore who is putting up 15.4 PPG in addition to 5.4 rebounds per game.

How to make Villanova vs. Syracuse picks

The model has simulated Syracuse vs. Villanova 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Villanova vs. Syracuse? And which side of the spread hits almost 60 percent of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that has returned over $2,200 on its college basketball picks the last five-plus years, and find out.