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The Winthrop Eagles and the South Carolina Upstate Spartans will face off in a Big South clash at 6 p.m. ET on Wednesday at the G.B. Hodge Center. South Carolina Upstate is 8-10 overall and 4-4 at home, while the Eagles are 12-7 overall and 3-6 on the road. Winthrop has won the last 10 head-to-head meetings and has also covered the spread in five of the last six matchups with SC Upstate.

However, SC Upstate is 10-5 against the spread this season while Winthrop is only 4-12 against the number. The Eagles are favored by seven points in the latest Winthrop vs. SC Upstate odds from Caesars Sportsbook, and the over-under is set at 144.5. Before entering any Winthrop vs. SC Upstate picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. It enters Week 12 of the season with a 49-36 record on all top-rated college basketball picks, returning almost $700. Over the past five-plus years, the proprietary computer model has generated an impressive profit of $2,800 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Carolina Upstate vs. Winthrop. You can head to SportsLine to see its picks. Here are several college basketball odds for Winthrop vs. SC Upstate:

  • Winthrop vs. SC Upstate spread: Winthrop -7
  • Winthrop vs. SC Upstate over-under: 144.5 points

What you need to know about South Carolina Upstate

South Carolina Upstate didn't have too much trouble with the Charleston Southern Buccaneers at home this past Saturday as it won 70-57. Jordan Gainey had 17 points and six assists in the victory while Bryson Mozone had 15 points and seven rebounds.

SC Upstate shot 7-for-16 from the 3-point line as a team and is now shooting a staggering 46.8 percent from beyond the arc during its current five-game winning streak. Gainey is shooting 51.3 percent from the 3-point line this season, ranking second nationally.

What you need to know about Winthrop

Meanwhile, Winthrop came up short against the High Point Panthers on Monday, falling 65-56. Kelton Talford had a double-double off the bench in the loss with 17 points and 10 rebounds, but the Eagles went just 4-for-24 from the 3-point line to end a six-game winning streak.

Third-year forward DJ Burns Jr. is averaging 15.6 points and 4.4 rebounds per game this season and he's reached double-digits in scoring in all but four games this year. Burns went 8-for-9 from the field and had 16 points in his most recent matchup with SC Upstate, a 107-77 win in December 2020.

How to make Winthrop vs. SC Upstate picks

The model has simulated South Carolina Upstate vs. Winthrop 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick where one side has all the value. You can only see the pick at SportsLine.

So who wins SC Upstate vs. Winthrop? And which side of the spread has all the value? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.