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The Wyoming Cowboys will take on the South Florida Bulls at 1:30 p.m. ET on Saturday at SimpliFI Arena in Honolulu as part of the 2021 Diamond Head Classic. The Cowboys are 10-2 on the season, while South Florida is 5-6. Wyoming began its tournament with a loss to Stanford in the opening round but then bested Northern Iowa in the consolation bracket to earn a bid in the fifth-place game.

Meanwhile, South Florida lost to BYU in the first round but defeated Hawaii in their second game. The Cowboys are favored by 7.5 points in the latest South Florida vs. Wyoming odds from Caesars Sportsbook, and the over-under is set at 122.5. Before entering any Wyoming vs. South Florida picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Wyoming vs. USF. You can head to SportsLine to see its picks. Here are several college basketball odds for USF vs. Wyoming:

  • South Florida vs. Wyoming spread: Wyoming -7.5
  • South Florida vs. Wyoming over-under: 122.5 points
Featured Game | South Florida Bulls vs. Wyoming Cowboys

What you need to know about South Florida

The Bulls bagged a 76-69 victory over the Hawaii Warriors on Friday. Javon Greene led the Bulls with 18 points in the victory on 4-of-8 shooting and Caleb Murphy had 17 points on 6-of-13 shooting while also contributing six assists. South Florida forced 14 turnovers in the win but only committed eight turnovers of its own.

Murphy was a top-100 recruit in the 247Sports college basketball recruiting rankings for the Class of 2020 and he's the team's leading scorer (12.6 ppg). Meanwhile, Greene is a transfer who scored 1,139 points at George Mason and is now averaging 10.2 points and 4.5 rebounds per game.

What you need to know about Wyoming

Meanwhile, Wyoming beat Northern Iowa by a 71-69 margin on Thursday. Guard Hunter Maldonado (17 points) and guard Drake Jeffries (16 points) were the top scorers for Wyoming. Leading scorer Graham Ike (19.4 ppg) also had 12 points on 5-of-5 shooting while playing just 17 minutes because he was battling foul trouble.

Jeff Linder's squad has four players averaging double-digits per game with Xavier DuSell (11.5 ppg) joining Ike, Maldonado (16.9 ppg) and Jeffries (10.8 ppg). The Cowboys are shooting 47.5 percent from the floor as a team this season while limiting opponents to 39.2 percent shooting.

How to make South Florida vs. Wyoming picks

The model is leaning over on the total and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Wyoming vs. South Florida? And which side of the spread hits over 60 percent of the time? Visit SportsLine now to find out, all from the red-hot model that has crushed its college basketball picks.