Get ready for a Big 12 battle as the TCU Horned Frogs and Iowa State Cyclones will face off at noon ET on Saturday at Jack Trice Stadium. Iowa State is 2-2 overall and 2-1 at home, while TCU is 3-1 overall and 1-0 on the road. TCU is 2-2 against the spread; Iowa State is 1-2-1. The Cyclones are favored by three points in the latest Iowa State vs. TCU odds, while the over-under is set at 43.5. Before you make any TCU vs. Iowa State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times, and those who have followed it have seen massive returns. Over the past four years, the proprietary computer model has generated a stunning $4,200 profit for $100 players on its top-rated college football against the spread picks. The model enters Week 6 of the 2019 college football season on a strong run, going 52-34 on its top-rated picks. It also called North Carolina (+27.5) covering with plenty of room to spare against Clemson and Ohio State (-17) easily covering against Nebraska last week. Anybody who has been following it is way up.

Now, it has simulated Iowa State vs. TCU 10,000 times and the results are in. We can tell you that the model is leaning under, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

It was a hard-fought game, but the Cyclones had to settle for a 23-21 defeat against Baylor last week. Iowa State's loss came about despite a quality game from quarterback Brock Purdy, who three for 342 yards and two touchdowns. Purdy has been impressive all season and comes into this matchup with over 1,300 yards of passing, eight touchdowns and two interceptions on the season. 

Meanwhile, TCU took care of business against Kansas as the Horned Frogs secured a 51-14 win. With that victory, the Horned Frogs brought their scoring average up a tier to 40.5 ppg. A couple defensive numbers to keep in mind before kickoff: The Cyclones enter the contest with only two rushing touchdowns allowed, good for seventh best in the nation. As for the Horned Frogs, they rank fourth in the league when it comes to yards allowed per game, with only 246 on average, so a low-scoring matchup is very probable this weekend. 

So who wins Iowa State vs. TCU? And which side of the spread has all the value? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.