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Rams running back Kyren Williams has played a major role in the offense since returning from an injury, averaging 25 touches in three games. He had 116 rushing yards on 25 carries against the Ravens last week, going over 100 rushing yards for the third time in his last four appearances. Williams has also been a weapon in the passing game, making him one of the top players in the Week 15 Fantasy football RB rankings. Is he the best running back to include in your Week 15 Fantasy football lineups?

Titans running back Derrick Henry has been one of the league's best players for years, but he has only surpassed 40 rushing yards twice in his last five games. Should you avoid him with your Week 15 Fantasy football strategy? Before you lock in any Fantasy football picks, be sure to check out the Week 15 Fantasy football rankings from the proven computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home emptyhanded.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 15 of the 2023 NFL season. Head to SportsLine now to see its Week 15 Fantasy football rankings.

Top Week 15 Fantasy football picks 

One player the model is high on this week: Browns tight end David Njoku. The 27-year-old ranks second among Cleveland's targets in the passing game, catching 59 passes for 600 yards and four touchdowns. He is coming off his best game of the season, hauling in six receptions for 91 yards and two scores against Jacksonville.

Njoku has posted a 15.7% target share with veteran quarterback Joe Flacco under center and ranks second among tight ends in end-zone targets since Week 7. He is facing a Chicago defense that has allowed the fifth-most Fantasy points and receptions per game to tight ends. Njoku is in line for another big performance this week, with the model listing him as a top-10 option at his position. 

A shocker: Dolphins wide receiver Jaylen Waddle, who has already piled up 242 catches for 3,193 yards and 18 touchdowns in his first 45 career games, stumbles big-time and barely fails to crack the top 30 at his position. He's a player to consider leaving on the bench ahead of a tough matchup against a Jets defense that ranks second in the NFL against the pass. Waddle is on pace for his third consecutive 1,000-yard season but after leading the NFL in yards per reception last year (18.1), the big plays have been harder to come by. 

He's been targeted 91 times over 12 games and has 63 receptions for 822 yards and three touchdowns. His target share drops from 23.6% to just 18.2% when Miami is in the red zone and those are all reasons why you should be wary of playing Waddle against an elite defensive opponent that held a high-flying Texans offense to 54 passing yards last week. For more start/sit Fantasy football advice, be sure to check out the rest of the Week 15 Fantasy football rankings.

How to set Week 15 Fantasy football rankings

The model is also calling for a shocking quarterback to finish in the top 10 of its Fantasy football QB rankings, ahead of stars like Dak Prescott and Patrick Mahomes. These picks could be the difference between winning big and going home with nothing. See the Week 15 Fantasy football rankings here.

So who should you start and sit this week, and which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 15 Fantasy football rankings for every position and see which shocking quarterback comes out of nowhere to crack the top 10, all from the model that has outperformed experts big-time.