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The New York Mets (47-28) and the Houston Astros (46-27) round out their two-game series on Wednesday afternoon in Queens, N.Y. Houston picked up a convincing 9-1 win over New York in the first game of this series. The Mets have dropped two straight games but will look to snap that skid and even the series 1-1.

First pitch is set for 1:10 p.m. ET from Citi Field. Houston is the -140 money line favorite (risk $140 to win $100) in the latest Astros vs. Mets odds from Caesars Sportsbook, while New York is a +120 underdog. The over-under for total runs scored is eight. Before making any Mets vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves as one of three best bets to win it all last season at +1000. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Astros vs. Mets, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Mets vs. Astros:

  • Astros vs. Mets money line: Houston -140, New York +120
  • Astros vs. Mets run line: New York +1.5 (-145)
  • Astros vs. Mets over-under: 8 runs
  • HOU: The Astros are 4-0 in their last 4 interleague games
  • NYM: The Mets are 13-3 in their last 16 home games
Featured Game | New York Mets vs. Houston Astros

Why you should back the Astros

Left fielder Yordan Alvarez continues to play fantastic ball through the first half of the season. Alvarez has quality athleticism with a nice combination of bat speed, control, and power. The 25-year-old produces runs for Houston's offense with consistency. Alvarez is eighth in the majors in batting average (.321), tied for second in home runs (23), and tied for fifth in RBIs (56). In yesterday's win, Alvarez went 3-for-3 with a two-run homer. 

First baseman Yuli Gurriel owns outstanding hands and bat speed. Gurriel can quickly turn on a pitch and shoot it into the gaps. He plays superb defense in the corner as he's a 2021 Gold Glove Winner. Gurriel currently has six home runs with 21 RBIs. The 38-year-old also logged a two-run home run in his last outing. 

Why you should back the Mets

First baseman Pete Alonso continues to play exceptional baseball. Alonso has remarkable power and drives the baseball a long way when he connects. He's connected quite often this year as Alonso is tied for fourth in the MLB in home runs (22) and first in RBI (69) with a batting average of .282.

Second baseman Jeff McNeil is one of the best contact hitters in the game as his .328 batting average ranks third in the National League. McNeil is a lifetime .303 hitter so this is no aberration, and he frequents the gaps at ballparks as his 17 doubles rank in the top 10 of the league. McNeil also offers positional versatility as he can also play third base and both corner outfield spots, so he's someone that rarely leaves the field.

How to make Mets vs. Astros picks

SportsLine's model is leaning over on the total, projecting 8.9 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Astros vs. Mets? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.