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Only one afternoon game is scheduled on Tuesday in Major League Baseball, and it will take place in Minneapolis. The Minnesota Twins host the Cleveland Indians in the first game of a day-night double-header at Target Field. Minnesota returns following a one-game jaunt to Yankee Stadium on Monday. In contrast, Cleveland had Monday off after a three-game set at home against the Milwaukee Brewers over the weekend.

Caesars Sportsbook lists the Twins as -121 money line favorites (risk $121 to win $100) for this 3:10 p.m. ET first pitch. The total number of runs Vegas thinks will be scored, or the over-under, is 6.5 in the latest Indians vs. Twins odds for this seven-inning matchup. Before making any Twins vs. Indians picks or MLB predictions, you need to see what SportsLine's advanced computer model has to say.

This model, which simulates every game 10,000 times, is 185-158 on top-rated MLB money-line picks through 24 weeks in the 2021 season, returning over $400. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some huge returns.

Now, the model has set its sights on Indians vs. Twins and just revealed its picks and predictions. You can head to SportsLine now to see its picks. Now, here are several MLB odds and betting trends for Twins vs. Indians:

  • Indians vs. Twins money line: Twins -121, Indians +110 
  • Indians vs. Twins over-under: 6.5 runs 
  • Indians vs. Twins run line: Twins -1.5 
  • CLE: The Indians are 33-36 in 2021 road games 
  • MIN: The Twins are 33-38 at home this season
Featured Game | Minnesota Twins vs. Cleveland Indians

Why you should back the Indians

Cleveland's offense is keyed by Jose Ramirez and Franmil Reyes, and that duo has been potent this season. Ramirez has 33 home runs in 2021, posting a blistering .538 slugging percentage and an impressive OPS of .885 this season. Reyes has 28 home runs in only 98 games, with a .540 slugging percentage and the ability to go deep at any time. As a team, the Indians also land No. 2 in the American League in stolen bases with 96, and that team speed puts pressure on the opposition. 

Cleveland is also a top-five team in triples with 20 this season, and Minnesota's bullpen is a glaring weakness. The Twins have an unsightly 4.48 ERA from their relief corps this season, and Minnesota's bullpen ranks second-worst in the American League in wins above replacement. Considering Cleveland's bullpen is a documented strength with a 3.69 ERA, that could swing the pendulum to the Indians.

Why you should back the Twins

Minnesota has the edge against Cleveland in head-to-head matchups this season, winning 10 of the 16 contests between the two squads. The Twins bring a lot of power to the table, belting 204 home runs (second in the AL) and posting a .422 slugging percentage. Minnesota is also patient to the tune of an 8.8 percent walk rate, and Cleveland's offense ranks in the bottom three of the American League in hits, batting average (.235) and on-base percentage (.303). 

Twins right-hander Joe Ryan takes the ball for his third career start, and he has been highly effective with a 2.25 ERA in his young career. Ryan is a bit of a mystery, but he threw seven innings while allowing one hit and no runs in his most recent outing, which happened to come against Cleveland.

How to make Indians vs. Twins picks

SportsLine's model is leaning under on the run total, and it says one side of the money line has all the value. You can only get the MLB model's picks at SportsLine.

So who wins Indians vs. Twins? And which side has all the value? Visit SportsLine now to find out which side of Indians vs. Twins you need to jump on Tuesday, all from the model that has crushed its MLB picks, and find out.